Does hydration status affect MRI measures of brain volume or water content?

Sandra M. Meyers, Roger Tam, Jimmy S. Lee, Shannon H. Kolind, Irene M. Vavasour, Emilie Mackie, Yinshan Zhao, Cornelia Laule, Burkhard Mädler, David K B Li, Alex L. MacKay, Anthony L. Traboulsee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: To determine whether differences in hydration state, which could arise from routine clinical procedures such as overnight fasting, affect brain total water content (TWC) and brain volume measured with magnetic resonance imaging (MRI). Materials and Methods: Twenty healthy volunteers were scanned with a 3T MR scanner four times: day 1, baseline scan; day 2, hydrated scan after consuming 3L of water over 12 hours; day 3, dehydrated scan after overnight fasting of 9 hours, followed by another scan 1 hour later for reproducibility. The following MRI data were collected: T2 relaxation (for TWC measurement), inversion recovery (for T1 measurement), and 3D T1-weighted (for brain volumes). Body weight and urine specific gravity were also measured. TWC was calculated by fitting the T2 relaxation data with a nonnegative least-squares algorithm, with corrections for T1 relaxation and image signal inhomogeneity and normalization to ventricular cerebrospinal fluid. Brain volume changes were measured using SIENA. TWC means were calculated within 14 tissue regions. Results: Despite indications of dehydration as demonstrated by increases in urine specific gravity (P = 0.03) and decreases in body weight (P = 0.001) between hydrated and dehydrated scans, there was no measurable change in TWC (within any brain region) or brain volume between hydration states. Conclusion: We demonstrate that within a range of physiologic conditions commonly encountered in routine clinical scans (no pretreatment with hydration, well hydrated before MRI, and overnight fasting), brain TWC and brain volumes are not substantially affected in a healthy control cohort. J. Magn. Reson. Imaging 2016;44:296–304.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume44
Issue number2
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Water
Brain
Fasting
Specific Gravity
Body Weight
Urine
Least-Squares Analysis
Dehydration
Cerebrospinal Fluid
Healthy Volunteers

Keywords

  • brain volume
  • hydration
  • magnetic resonance
  • proton density
  • T2 relaxation
  • water content

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Meyers, S. M., Tam, R., Lee, J. S., Kolind, S. H., Vavasour, I. M., Mackie, E., ... Traboulsee, A. L. (2016). Does hydration status affect MRI measures of brain volume or water content? Journal of Magnetic Resonance Imaging, 44(2), 296-304. https://doi.org/10.1002/jmri.25168

Does hydration status affect MRI measures of brain volume or water content? / Meyers, Sandra M.; Tam, Roger; Lee, Jimmy S.; Kolind, Shannon H.; Vavasour, Irene M.; Mackie, Emilie; Zhao, Yinshan; Laule, Cornelia; Mädler, Burkhard; Li, David K B; MacKay, Alex L.; Traboulsee, Anthony L.

In: Journal of Magnetic Resonance Imaging, Vol. 44, No. 2, 01.08.2016, p. 296-304.

Research output: Contribution to journalArticle

Meyers, SM, Tam, R, Lee, JS, Kolind, SH, Vavasour, IM, Mackie, E, Zhao, Y, Laule, C, Mädler, B, Li, DKB, MacKay, AL & Traboulsee, AL 2016, 'Does hydration status affect MRI measures of brain volume or water content?', Journal of Magnetic Resonance Imaging, vol. 44, no. 2, pp. 296-304. https://doi.org/10.1002/jmri.25168
Meyers, Sandra M. ; Tam, Roger ; Lee, Jimmy S. ; Kolind, Shannon H. ; Vavasour, Irene M. ; Mackie, Emilie ; Zhao, Yinshan ; Laule, Cornelia ; Mädler, Burkhard ; Li, David K B ; MacKay, Alex L. ; Traboulsee, Anthony L. / Does hydration status affect MRI measures of brain volume or water content?. In: Journal of Magnetic Resonance Imaging. 2016 ; Vol. 44, No. 2. pp. 296-304.
@article{ab0498889ecb4a71a2db01f84a6aeec1,
title = "Does hydration status affect MRI measures of brain volume or water content?",
abstract = "Purpose: To determine whether differences in hydration state, which could arise from routine clinical procedures such as overnight fasting, affect brain total water content (TWC) and brain volume measured with magnetic resonance imaging (MRI). Materials and Methods: Twenty healthy volunteers were scanned with a 3T MR scanner four times: day 1, baseline scan; day 2, hydrated scan after consuming 3L of water over 12 hours; day 3, dehydrated scan after overnight fasting of 9 hours, followed by another scan 1 hour later for reproducibility. The following MRI data were collected: T2 relaxation (for TWC measurement), inversion recovery (for T1 measurement), and 3D T1-weighted (for brain volumes). Body weight and urine specific gravity were also measured. TWC was calculated by fitting the T2 relaxation data with a nonnegative least-squares algorithm, with corrections for T1 relaxation and image signal inhomogeneity and normalization to ventricular cerebrospinal fluid. Brain volume changes were measured using SIENA. TWC means were calculated within 14 tissue regions. Results: Despite indications of dehydration as demonstrated by increases in urine specific gravity (P = 0.03) and decreases in body weight (P = 0.001) between hydrated and dehydrated scans, there was no measurable change in TWC (within any brain region) or brain volume between hydration states. Conclusion: We demonstrate that within a range of physiologic conditions commonly encountered in routine clinical scans (no pretreatment with hydration, well hydrated before MRI, and overnight fasting), brain TWC and brain volumes are not substantially affected in a healthy control cohort. J. Magn. Reson. Imaging 2016;44:296–304.",
keywords = "brain volume, hydration, magnetic resonance, proton density, T2 relaxation, water content",
author = "Meyers, {Sandra M.} and Roger Tam and Lee, {Jimmy S.} and Kolind, {Shannon H.} and Vavasour, {Irene M.} and Emilie Mackie and Yinshan Zhao and Cornelia Laule and Burkhard M{\"a}dler and Li, {David K B} and MacKay, {Alex L.} and Traboulsee, {Anthony L.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1002/jmri.25168",
language = "English (US)",
volume = "44",
pages = "296--304",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Does hydration status affect MRI measures of brain volume or water content?

AU - Meyers, Sandra M.

AU - Tam, Roger

AU - Lee, Jimmy S.

AU - Kolind, Shannon H.

AU - Vavasour, Irene M.

AU - Mackie, Emilie

AU - Zhao, Yinshan

AU - Laule, Cornelia

AU - Mädler, Burkhard

AU - Li, David K B

AU - MacKay, Alex L.

AU - Traboulsee, Anthony L.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Purpose: To determine whether differences in hydration state, which could arise from routine clinical procedures such as overnight fasting, affect brain total water content (TWC) and brain volume measured with magnetic resonance imaging (MRI). Materials and Methods: Twenty healthy volunteers were scanned with a 3T MR scanner four times: day 1, baseline scan; day 2, hydrated scan after consuming 3L of water over 12 hours; day 3, dehydrated scan after overnight fasting of 9 hours, followed by another scan 1 hour later for reproducibility. The following MRI data were collected: T2 relaxation (for TWC measurement), inversion recovery (for T1 measurement), and 3D T1-weighted (for brain volumes). Body weight and urine specific gravity were also measured. TWC was calculated by fitting the T2 relaxation data with a nonnegative least-squares algorithm, with corrections for T1 relaxation and image signal inhomogeneity and normalization to ventricular cerebrospinal fluid. Brain volume changes were measured using SIENA. TWC means were calculated within 14 tissue regions. Results: Despite indications of dehydration as demonstrated by increases in urine specific gravity (P = 0.03) and decreases in body weight (P = 0.001) between hydrated and dehydrated scans, there was no measurable change in TWC (within any brain region) or brain volume between hydration states. Conclusion: We demonstrate that within a range of physiologic conditions commonly encountered in routine clinical scans (no pretreatment with hydration, well hydrated before MRI, and overnight fasting), brain TWC and brain volumes are not substantially affected in a healthy control cohort. J. Magn. Reson. Imaging 2016;44:296–304.

AB - Purpose: To determine whether differences in hydration state, which could arise from routine clinical procedures such as overnight fasting, affect brain total water content (TWC) and brain volume measured with magnetic resonance imaging (MRI). Materials and Methods: Twenty healthy volunteers were scanned with a 3T MR scanner four times: day 1, baseline scan; day 2, hydrated scan after consuming 3L of water over 12 hours; day 3, dehydrated scan after overnight fasting of 9 hours, followed by another scan 1 hour later for reproducibility. The following MRI data were collected: T2 relaxation (for TWC measurement), inversion recovery (for T1 measurement), and 3D T1-weighted (for brain volumes). Body weight and urine specific gravity were also measured. TWC was calculated by fitting the T2 relaxation data with a nonnegative least-squares algorithm, with corrections for T1 relaxation and image signal inhomogeneity and normalization to ventricular cerebrospinal fluid. Brain volume changes were measured using SIENA. TWC means were calculated within 14 tissue regions. Results: Despite indications of dehydration as demonstrated by increases in urine specific gravity (P = 0.03) and decreases in body weight (P = 0.001) between hydrated and dehydrated scans, there was no measurable change in TWC (within any brain region) or brain volume between hydration states. Conclusion: We demonstrate that within a range of physiologic conditions commonly encountered in routine clinical scans (no pretreatment with hydration, well hydrated before MRI, and overnight fasting), brain TWC and brain volumes are not substantially affected in a healthy control cohort. J. Magn. Reson. Imaging 2016;44:296–304.

KW - brain volume

KW - hydration

KW - magnetic resonance

KW - proton density

KW - T2 relaxation

KW - water content

UR - http://www.scopus.com/inward/record.url?scp=84990182163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990182163&partnerID=8YFLogxK

U2 - 10.1002/jmri.25168

DO - 10.1002/jmri.25168

M3 - Article

C2 - 26825048

AN - SCOPUS:84990182163

VL - 44

SP - 296

EP - 304

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -