Does epilepsy cause a reversion to immature function?

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Seizures have variable effects on brain. Numerous studies have examined the consequences of seizures, in light of the way that these may alter the susceptibility of the brain to seizures, promote epileptogenesis, or functionally alter brain leading to seizure-related comorbidities. In many -but not all- situations, seizures shift brain function towards a more immature state, promoting the birth of newborn neurons, altering the dendritic structure and neuronal connectivity, or changing neurotransmitter signaling towards more immature patterns. These effects depend upon many factors, including the seizure type, age of seizure occurrence, sex, and brain region studied. Here we discuss some of these findings proposing that these seizure-induced immature features do not simply represent rejuvenation of the brain but rather a de-synchronization of the homeostatic mechanisms that were in place to maintain normal physiology, which may contribute to epileptogenesis or the cognitive comorbidities.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages195-209
Number of pages15
Volume813
ISBN (Print)9789401789134
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume813
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Epilepsy
Brain
Seizures
Comorbidity
Physiology
Rejuvenation
Neurons
Neurotransmitter Agents
Synchronization
Parturition

Keywords

  • Chloride cotransporter
  • Dysplasia
  • Epileptogenesis
  • GABA receptor
  • mTOR
  • Neurogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Galanopoulou, A. S., & Moshe, S. L. (2014). Does epilepsy cause a reversion to immature function? In Advances in Experimental Medicine and Biology (Vol. 813, pp. 195-209). (Advances in Experimental Medicine and Biology; Vol. 813). Springer New York LLC. https://doi.org/10.1007/978-94-17-8914-1_16

Does epilepsy cause a reversion to immature function? / Galanopoulou, Aristea S.; Moshe, Solomon L.

Advances in Experimental Medicine and Biology. Vol. 813 Springer New York LLC, 2014. p. 195-209 (Advances in Experimental Medicine and Biology; Vol. 813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Galanopoulou, AS & Moshe, SL 2014, Does epilepsy cause a reversion to immature function? in Advances in Experimental Medicine and Biology. vol. 813, Advances in Experimental Medicine and Biology, vol. 813, Springer New York LLC, pp. 195-209. https://doi.org/10.1007/978-94-17-8914-1_16
Galanopoulou AS, Moshe SL. Does epilepsy cause a reversion to immature function? In Advances in Experimental Medicine and Biology. Vol. 813. Springer New York LLC. 2014. p. 195-209. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-17-8914-1_16
Galanopoulou, Aristea S. ; Moshe, Solomon L. / Does epilepsy cause a reversion to immature function?. Advances in Experimental Medicine and Biology. Vol. 813 Springer New York LLC, 2014. pp. 195-209 (Advances in Experimental Medicine and Biology).
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