DNA content in correlation with postsurgical stage in non-small cell lung cancer

Ned Z. Carp, Douglas D. Ellison, Patrick F. Brophy, Perry Watts, Ming Chen Chang, Steven M. Keller

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The relationship between DNA content, TNM stage, tumor size, grade, histology, and disease-free survival was assessed in a retrospective study of patients with non-small cell lung cancer who had undergone resection and complete mediastinal lymph node dissection. Flow cytometric analysis was performed on paraffin-embedded tissue of 90 consecutive patients. The patients were analyzed both as a group and by individual stage. Median follow-up was 11 months (range, 1 to 35 months). Aneuploid tumors were not significantly different from diploid tumors with regard to pathologic TNM stage (p = 0.34), size (p = 0.5), grade (p = 0.5), or histology (p = 0.34). Disease-free survival of patients with aneuploid tumors was not significantly different than that of patients whose tumors had normal DNA content (p = 0.69). DNA content did not correlate with established prognostic factors in patients with non-small cell lung cancer who underwent resection and complete mediastinal lymph node dissection.

Original languageEnglish (US)
Pages (from-to)680-683
Number of pages4
JournalThe Annals of thoracic surgery
Volume53
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

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Non-Small Cell Lung Carcinoma
DNA
Aneuploidy
Neoplasms
Lymph Node Excision
Disease-Free Survival
Histology
Diploidy
Paraffin
Retrospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Carp, N. Z., Ellison, D. D., Brophy, P. F., Watts, P., Chang, M. C., & Keller, S. M. (1992). DNA content in correlation with postsurgical stage in non-small cell lung cancer. The Annals of thoracic surgery, 53(4), 680-683. https://doi.org/10.1016/0003-4975(92)90333-Y

DNA content in correlation with postsurgical stage in non-small cell lung cancer. / Carp, Ned Z.; Ellison, Douglas D.; Brophy, Patrick F.; Watts, Perry; Chang, Ming Chen; Keller, Steven M.

In: The Annals of thoracic surgery, Vol. 53, No. 4, 1992, p. 680-683.

Research output: Contribution to journalArticle

Carp, NZ, Ellison, DD, Brophy, PF, Watts, P, Chang, MC & Keller, SM 1992, 'DNA content in correlation with postsurgical stage in non-small cell lung cancer', The Annals of thoracic surgery, vol. 53, no. 4, pp. 680-683. https://doi.org/10.1016/0003-4975(92)90333-Y
Carp, Ned Z. ; Ellison, Douglas D. ; Brophy, Patrick F. ; Watts, Perry ; Chang, Ming Chen ; Keller, Steven M. / DNA content in correlation with postsurgical stage in non-small cell lung cancer. In: The Annals of thoracic surgery. 1992 ; Vol. 53, No. 4. pp. 680-683.
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