DNA content in correlation with postsurgical stage in non-small cell lung cancer

Ned Z. Carp, Douglas D. Ellison, Patrick F. Brophy, Perry Watts, Ming Chen Chang, Steven M. Keller

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The relationship between DNA content, TNM stage, tumor size, grade, histology, and disease-free survival was assessed in a retrospective study of patients with non-small cell lung cancer who had undergone resection and complete mediastinal lymph node dissection. Flow cytometric analysis was performed on paraffin-embedded tissue of 90 consecutive patients. The patients were analyzed both as a group and by individual stage. Median follow-up was 11 months (range, 1 to 35 months). Aneuploid tumors were not significantly different from diploid tumors with regard to pathologic TNM stage (p = 0.34), size (p = 0.5), grade (p = 0.5), or histology (p = 0.34). Disease-free survival of patients with aneuploid tumors was not significantly different than that of patients whose tumors had normal DNA content (p = 0.69). DNA content did not correlate with established prognostic factors in patients with non-small cell lung cancer who underwent resection and complete mediastinal lymph node dissection.

Original languageEnglish (US)
Pages (from-to)680-683
Number of pages4
JournalThe Annals of Thoracic Surgery
Volume53
Issue number4
DOIs
StatePublished - Apr 1992

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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