Diversin regulates heart formation and gastrulation movements in development

Heinz Moeller, Andreas Jenny, Hans Joerg Schaeffer, Thomas Schwarz-Romond, Marek Mlodzik, Matthias Hammerschmidt, Walter Birchmeier

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Canonical and noncanonical Wnt signaling regulate crucial events in the development of vertebrates and invertebrates. In this work we show that vertebrate Diversin, a potential orthologue of Drosophila Diego, controls fusion of heart precursors and gastrulation movements in zebrafish embryogenesis. These events are regulated by noncanonical Wnt signaling, which is independent of β-catenin. We found that Diversin directly interacts with Dishevelled and that this interaction is necessary and sufficient to mediate signals of the noncanonical Wnt pathway to downstream effectors like Rho family GTPases and Jun N-terminal kinase. The ankyrin repeats of Diversin are required for the interaction with Dishevelled, for the activation of noncanonical Wnt signaling, and for the biological responses. The mutation K446M in the DEP domain of vertebrate Dishevelled, which mimics a classical Drosophila loss of function mutation, prevents functional interaction with Diversin's ankyrin repeats. Diversin also affects planar cell polarity in Drosophila, which is controlled by the noncanonical Wnt signaling pathway. Our data thus demonstrate that Diversin and Dishevelled function together in a mutually dependent fashion in zebrafish gastrulation and organ formation.

Original languageEnglish (US)
Pages (from-to)15900-15905
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number43
StatePublished - Oct 24 2006
Externally publishedYes


  • Convergence and extension
  • Dishevelled
  • Embryogenesis
  • Noncanonical Wnt signaling
  • Rho family GTPases

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Diversin regulates heart formation and gastrulation movements in development'. Together they form a unique fingerprint.

Cite this