Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms

Marzieh Majd, Jennifer E. Graham-Engeland, Joshua M. Smyth, Martin J. Sliwinski, Richard B. Lipton, Mindy Joy Katz, Christopher G. Engeland

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Extensive research links depression and inflammation, with emerging evidence suggesting some differences between males and females in these associations. However, relatively few studies have examined stimulated inflammatory responses (ex vivo) in depression. The present research investigated the associations between depressive symptoms, basal inflammation, and LPS-stimulated production of pro- (IL-1β, IL-6, IL-8, TNF-α) and an anti-inflammatory cytokine (IL-10), with a focus on the extent to which gender moderates these relationships. As part of a larger study, 162 socio-economically and racially diverse subjects (ages 25–65, 67% women) completed extensive self-report measures, including depressive symptoms. Whole blood was quantified for basal inflammation, or incubated with 1 μg/mL lipopolysaccharide (LPS) for 2 h (at 37 °C, 5% CO2) to quantify inflammatory responses to bacterial challenge. We examined the associations between depression and inflammatory markers in regression analyses, controlling for age, BMI, race/ethnicity, income, education, and use of medications. No main effects were observed between depressive symptoms and basal or stimulated levels of inflammation. Moderation analyses revealed a significant interaction between depressive symptoms and gender for stimulated TNF-α, stimulated IL-6 (p < 0.05), and a marginally significant interaction for stimulated IL-10 (p = 0.07). For men, higher depressive symptoms were associated with significantly higher production of TNF-α (p < 0.05) and marginally higher IL-6 (p = 0.07), but not with the anti-inflammatory cytokine IL-10. For women, higher depressive symptoms were associated with significantly lower production of TNF-α and IL-10 (ps < 0.05), and marginally lower IL-6 (p = 0.06). These findings provide evidence for gender differences in the association of depressive symptoms with inflammatory response patterns, and highlight the utility of assessing ex vivo immune responses in blood. Implications for health are discussed.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalPhysiology and Behavior
Volume184
DOIs
StatePublished - Feb 1 2018

Fingerprint

Depression
Interleukin-10
Interleukin-6
Inflammation
Lipopolysaccharides
Anti-Inflammatory Agents
Cytokines
Interleukin-8
Interleukin-1
Research
Self Report
Regression Analysis
Education
Health

Keywords

  • Cytokine
  • Depression
  • Endotoxin
  • Inflammation
  • Inflammatory response
  • LPS

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms. / Majd, Marzieh; Graham-Engeland, Jennifer E.; Smyth, Joshua M.; Sliwinski, Martin J.; Lipton, Richard B.; Katz, Mindy Joy; Engeland, Christopher G.

In: Physiology and Behavior, Vol. 184, 01.02.2018, p. 108-115.

Research output: Contribution to journalArticle

Majd, Marzieh ; Graham-Engeland, Jennifer E. ; Smyth, Joshua M. ; Sliwinski, Martin J. ; Lipton, Richard B. ; Katz, Mindy Joy ; Engeland, Christopher G. / Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms. In: Physiology and Behavior. 2018 ; Vol. 184. pp. 108-115.
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abstract = "Extensive research links depression and inflammation, with emerging evidence suggesting some differences between males and females in these associations. However, relatively few studies have examined stimulated inflammatory responses (ex vivo) in depression. The present research investigated the associations between depressive symptoms, basal inflammation, and LPS-stimulated production of pro- (IL-1β, IL-6, IL-8, TNF-α) and an anti-inflammatory cytokine (IL-10), with a focus on the extent to which gender moderates these relationships. As part of a larger study, 162 socio-economically and racially diverse subjects (ages 25–65, 67{\%} women) completed extensive self-report measures, including depressive symptoms. Whole blood was quantified for basal inflammation, or incubated with 1 μg/mL lipopolysaccharide (LPS) for 2 h (at 37 °C, 5{\%} CO2) to quantify inflammatory responses to bacterial challenge. We examined the associations between depression and inflammatory markers in regression analyses, controlling for age, BMI, race/ethnicity, income, education, and use of medications. No main effects were observed between depressive symptoms and basal or stimulated levels of inflammation. Moderation analyses revealed a significant interaction between depressive symptoms and gender for stimulated TNF-α, stimulated IL-6 (p < 0.05), and a marginally significant interaction for stimulated IL-10 (p = 0.07). For men, higher depressive symptoms were associated with significantly higher production of TNF-α (p < 0.05) and marginally higher IL-6 (p = 0.07), but not with the anti-inflammatory cytokine IL-10. For women, higher depressive symptoms were associated with significantly lower production of TNF-α and IL-10 (ps < 0.05), and marginally lower IL-6 (p = 0.06). These findings provide evidence for gender differences in the association of depressive symptoms with inflammatory response patterns, and highlight the utility of assessing ex vivo immune responses in blood. Implications for health are discussed.",
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