Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment

Missak Haigentz, Dana M. Hartl, Carl E. Silver, Johannes A. Langendijk, Primož Strojan, Vinidh Paleri, Remco De Bree, Jean Pascal MacHiels, Marc Hamoir, Alessandra Rinaldo, Daniela Paccagnella, Ashok R. Shaha, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journalReview article

28 Scopus citations


Distant metastases from head and neck squamous cell carcinoma (HNSCC), though rare at initial presentation, remain an important manifestation of cancer recurrence and mortality. Although generally considered incurable with a dismal prognosis despite palliative therapy, highly selected patients with distant metastases may have a long term survival benefit from aggressive surgery or radiotherapy. Advances in systemic treatments also may improve patient survival. This article reviews the current state of management of HNSCC patients with distant metastases.

Original languageEnglish (US)
Pages (from-to)787-793
Number of pages7
JournalOral Oncology
Issue number9
StatePublished - Sep 1 2012



  • Chemotherapy
  • Distant metastases
  • Head and neck squamous cell carcinoma
  • Metastasectomy
  • Treatment

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Haigentz, M., Hartl, D. M., Silver, C. E., Langendijk, J. A., Strojan, P., Paleri, V., De Bree, R., MacHiels, J. P., Hamoir, M., Rinaldo, A., Paccagnella, D., Shaha, A. R., Takes, R. P., & Ferlito, A. (2012). Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment. Oral Oncology, 48(9), 787-793. https://doi.org/10.1016/j.oraloncology.2012.03.019