Disseminated Adenovirus Disease Presenting as Septic Shock in an Immunocompetent Pubertal Girl

Research output: Contribution to journalArticle

Abstract

Adenovirus is a common cause of respiratory illness in childhood and is associated with approximately 5% to 15% of upper and lower respiratory tract infections. Immunocompetent individuals usually have a mild and self-limited disease course, with syndromes typically including pharyngitis, bronchiolitis, keratoconjunctivitis, otitis media, and gastroenteritis. Neurologic manifestations in immunocompetent children are less common and include aseptic meningitis, myelitis, subacute focal encephalitis, seizures, paralysis, and Reye-like syndrome. Disseminated adenovirus disease is rare in immunocompetent children, occurring in approximately 1% to 1.5% of all cases of adenovirus infection compared with a 12.5% occurrence rate in immunocompromised children. Furthermore, to the best of our knowledge, disseminated adenovirus disease causing a severe sepsis-like picture in an immunocompetent child has only been described in 1 published report. Here, we present a case of a previously healthy pubertal girl who presented in severe hypotensive shock and who subsequently had adenovirus DNA detected from the cerebrospinal fluid and no other etiology identified.

Original languageEnglish (US)
Pages (from-to)e25-e27
JournalInfectious Diseases in Clinical Practice
Volume26
Issue number5
DOIs
StatePublished - Sep 1 2018

Fingerprint

Septic Shock
Adenoviridae
Reye Syndrome
Myelitis
Keratoconjunctivitis
Aseptic Meningitis
Adenoviridae Infections
Bronchiolitis
Pharyngitis
Gastroenteritis
Otitis Media
Encephalitis
Rare Diseases
Neurologic Manifestations
Paralysis
Respiratory Tract Infections
Cerebrospinal Fluid
Shock
Sepsis
Seizures

Keywords

  • adenovirus
  • immunocompetent
  • puberty
  • viral sepsis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Disseminated Adenovirus Disease Presenting as Septic Shock in an Immunocompetent Pubertal Girl",
abstract = "Adenovirus is a common cause of respiratory illness in childhood and is associated with approximately 5{\%} to 15{\%} of upper and lower respiratory tract infections. Immunocompetent individuals usually have a mild and self-limited disease course, with syndromes typically including pharyngitis, bronchiolitis, keratoconjunctivitis, otitis media, and gastroenteritis. Neurologic manifestations in immunocompetent children are less common and include aseptic meningitis, myelitis, subacute focal encephalitis, seizures, paralysis, and Reye-like syndrome. Disseminated adenovirus disease is rare in immunocompetent children, occurring in approximately 1{\%} to 1.5{\%} of all cases of adenovirus infection compared with a 12.5{\%} occurrence rate in immunocompromised children. Furthermore, to the best of our knowledge, disseminated adenovirus disease causing a severe sepsis-like picture in an immunocompetent child has only been described in 1 published report. Here, we present a case of a previously healthy pubertal girl who presented in severe hypotensive shock and who subsequently had adenovirus DNA detected from the cerebrospinal fluid and no other etiology identified.",
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N2 - Adenovirus is a common cause of respiratory illness in childhood and is associated with approximately 5% to 15% of upper and lower respiratory tract infections. Immunocompetent individuals usually have a mild and self-limited disease course, with syndromes typically including pharyngitis, bronchiolitis, keratoconjunctivitis, otitis media, and gastroenteritis. Neurologic manifestations in immunocompetent children are less common and include aseptic meningitis, myelitis, subacute focal encephalitis, seizures, paralysis, and Reye-like syndrome. Disseminated adenovirus disease is rare in immunocompetent children, occurring in approximately 1% to 1.5% of all cases of adenovirus infection compared with a 12.5% occurrence rate in immunocompromised children. Furthermore, to the best of our knowledge, disseminated adenovirus disease causing a severe sepsis-like picture in an immunocompetent child has only been described in 1 published report. Here, we present a case of a previously healthy pubertal girl who presented in severe hypotensive shock and who subsequently had adenovirus DNA detected from the cerebrospinal fluid and no other etiology identified.

AB - Adenovirus is a common cause of respiratory illness in childhood and is associated with approximately 5% to 15% of upper and lower respiratory tract infections. Immunocompetent individuals usually have a mild and self-limited disease course, with syndromes typically including pharyngitis, bronchiolitis, keratoconjunctivitis, otitis media, and gastroenteritis. Neurologic manifestations in immunocompetent children are less common and include aseptic meningitis, myelitis, subacute focal encephalitis, seizures, paralysis, and Reye-like syndrome. Disseminated adenovirus disease is rare in immunocompetent children, occurring in approximately 1% to 1.5% of all cases of adenovirus infection compared with a 12.5% occurrence rate in immunocompromised children. Furthermore, to the best of our knowledge, disseminated adenovirus disease causing a severe sepsis-like picture in an immunocompetent child has only been described in 1 published report. Here, we present a case of a previously healthy pubertal girl who presented in severe hypotensive shock and who subsequently had adenovirus DNA detected from the cerebrospinal fluid and no other etiology identified.

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