TY - JOUR
T1 - Discrimination between urticaria-prone and other allergic patients by intradermal skin testing with codeine
AU - Cohen, Russell W.
AU - Rosenstreich, David L.
N1 - Funding Information:
From the Departments of Medicine and Microbiology and Immu-nology, Albai Einstein College of Medicine, Bronx, N. Y. Supported in put by AECOM Cancer Center Core Grant No. P3O-CA-13330 and National Institutes of Health Grant No. ROl A&17934. Received for publication May 13, 1985. Accepted for publication Nov. 27, 1985. Reprint requests: David L. Rosenstreich, M.D., Albert Einstein College of Medicine, Chanin Building, Rm. 628, 1300 Morris Park Ave., Bronx, NY 10461.
PY - 1986/6
Y1 - 1986/6
N2 - To study the ability of cutaneous mast cells to degranulate in urticaria-prone patients, subjects were skin tested with the known mast cell degranulator, codeine sulfate. Sensitivity to codeine as determined by the concentrations of codeine necessary to cause a net wheal of 5 mm was compared between urticaria-prone subjects, allergic subjects, and normal control subjects. Urticaria-prone subjects were more sensitive to codeine at every concentration tested and exhibited a mean reactivity to codeine that was almost 100 times that of the other allergic individuals and normal control subjects. This difference could not be explained by an increased sensitivity to histamine in 71% of urticaria-prone patients nor by any dermatographic tendencies or increased relative allergic reactivity. These findings suggest that codeine skin testing can be used to identify a distinct population of patients with urticaria.
AB - To study the ability of cutaneous mast cells to degranulate in urticaria-prone patients, subjects were skin tested with the known mast cell degranulator, codeine sulfate. Sensitivity to codeine as determined by the concentrations of codeine necessary to cause a net wheal of 5 mm was compared between urticaria-prone subjects, allergic subjects, and normal control subjects. Urticaria-prone subjects were more sensitive to codeine at every concentration tested and exhibited a mean reactivity to codeine that was almost 100 times that of the other allergic individuals and normal control subjects. This difference could not be explained by an increased sensitivity to histamine in 71% of urticaria-prone patients nor by any dermatographic tendencies or increased relative allergic reactivity. These findings suggest that codeine skin testing can be used to identify a distinct population of patients with urticaria.
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U2 - 10.1016/0091-6749(86)90377-5
DO - 10.1016/0091-6749(86)90377-5
M3 - Article
C2 - 3711548
AN - SCOPUS:0022549529
SN - 0091-6749
VL - 77
SP - 802
EP - 807
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 6
ER -