Discrimination between urticaria-prone and other allergic patients by intradermal skin testing with codeine

Russell W. Cohen, David L. Rosenstreich

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

To study the ability of cutaneous mast cells to degranulate in urticaria-prone patients, subjects were skin tested with the known mast cell degranulator, codeine sulfate. Sensitivity to codeine as determined by the concentrations of codeine necessary to cause a net wheal of 5 mm was compared between urticaria-prone subjects, allergic subjects, and normal control subjects. Urticaria-prone subjects were more sensitive to codeine at every concentration tested and exhibited a mean reactivity to codeine that was almost 100 times that of the other allergic individuals and normal control subjects. This difference could not be explained by an increased sensitivity to histamine in 71% of urticaria-prone patients nor by any dermatographic tendencies or increased relative allergic reactivity. These findings suggest that codeine skin testing can be used to identify a distinct population of patients with urticaria.

Original languageEnglish (US)
Pages (from-to)802-807
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume77
Issue number6
DOIs
StatePublished - 1986

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Codeine
Urticaria
Skin
Mast Cells
Histamine
Sulfates
Population

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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abstract = "To study the ability of cutaneous mast cells to degranulate in urticaria-prone patients, subjects were skin tested with the known mast cell degranulator, codeine sulfate. Sensitivity to codeine as determined by the concentrations of codeine necessary to cause a net wheal of 5 mm was compared between urticaria-prone subjects, allergic subjects, and normal control subjects. Urticaria-prone subjects were more sensitive to codeine at every concentration tested and exhibited a mean reactivity to codeine that was almost 100 times that of the other allergic individuals and normal control subjects. This difference could not be explained by an increased sensitivity to histamine in 71{\%} of urticaria-prone patients nor by any dermatographic tendencies or increased relative allergic reactivity. These findings suggest that codeine skin testing can be used to identify a distinct population of patients with urticaria.",
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