Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

Gangli Gong; Yuli Xie; Yidong Liu; Alison Rinderspacher; Shi Xian Deng; Yan Feng; Zhengxiang Zhu; Yufei Tang; Michael Wyler; Nathalie Aulner; Udo Toebben; Deborah H. Smith; Lars Branden; Caty Chung; Stephan Schürer; Dušica Vidović; Donald W. Landry

doi:10.1016/j.bmcl.2008.12.086

Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

Gangli Gong, Yuli Xie, Yidong Liu, Alison Rinderspacher, Shi Xian Deng, Yan Feng, Zhengxiang Zhu, Yufei Tang, Michael Wyler, Nathalie Aulner, Udo Toebben, Deborah H. Smith, Lars Branden, Caty Chung, Stephan Schürer, Dušica Vidović, Donald W. Landry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

Original language	English (US)
Pages (from-to)	1191-1194
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2008.12.086
State	Published - Feb 15 2009
Externally published	Yes

Keywords

Activator
HUVEC cells
NF-κB
Quinazoline

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2008.12.086

Cite this

Gong, G., Xie, Y., Liu, Y., Rinderspacher, A., Deng, S. X., Feng, Y., Zhu, Z., Tang, Y., Wyler, M., Aulner, N., Toebben, U., Smith, D. H., Branden, L., Chung, C., Schürer, S., Vidović, D., & Landry, D. W. (2009). Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation. Bioorganic and Medicinal Chemistry Letters, 19(4), 1191-1194. https://doi.org/10.1016/j.bmcl.2008.12.086

Gong, G, Xie, Y, Liu, Y, Rinderspacher, A, Deng, SX, Feng, Y, Zhu, Z, Tang, Y, Wyler, M, Aulner, N, Toebben, U, Smith, DH, Branden, L, Chung, C, Schürer, S, Vidović, D & Landry, DW 2009, 'Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 4, pp. 1191-1194. https://doi.org/10.1016/j.bmcl.2008.12.086

@article{26ca165c63504915a40eb707b1f87c2e,

title = "Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation",

abstract = "An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.",

keywords = "Activator, HUVEC cells, NF-κB, Quinazoline",

author = "Gangli Gong and Yuli Xie and Yidong Liu and Alison Rinderspacher and Deng, {Shi Xian} and Yan Feng and Zhengxiang Zhu and Yufei Tang and Michael Wyler and Nathalie Aulner and Udo Toebben and Smith, {Deborah H.} and Lars Branden and Caty Chung and Stephan Sch{\"u}rer and Du{\v s}ica Vidovi{\'c} and Landry, {Donald W.}",

year = "2009",

month = feb,

day = "15",

doi = "10.1016/j.bmcl.2008.12.086",

language = "English (US)",

volume = "19",

pages = "1191--1194",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

AU - Gong, Gangli

AU - Xie, Yuli

AU - Liu, Yidong

AU - Rinderspacher, Alison

AU - Deng, Shi Xian

AU - Feng, Yan

AU - Zhu, Zhengxiang

AU - Tang, Yufei

AU - Wyler, Michael

AU - Aulner, Nathalie

AU - Toebben, Udo

AU - Smith, Deborah H.

AU - Branden, Lars

AU - Chung, Caty

AU - Schürer, Stephan

AU - Vidović, Dušica

AU - Landry, Donald W.

PY - 2009/2/15

Y1 - 2009/2/15

N2 - An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

AB - An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

KW - Activator

KW - HUVEC cells

KW - NF-κB

KW - Quinazoline

UR - http://www.scopus.com/inward/record.url?scp=59649092365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59649092365&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2008.12.086

DO - 10.1016/j.bmcl.2008.12.086

M3 - Article

C2 - 19136257

AN - SCOPUS:59649092365

SN - 0960-894X

VL - 19

SP - 1191

EP - 1194

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this