Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

Yuli Xie; Yidong Liu; Gangli Gong; Alison Rinderspacher; Shi Xian Deng; Deborah H. Smith; Udo Toebben; Effie Tzilianos; Lars Branden; Dušica Vidović; Caty Chung; Stephan Schürer; Lutz Tautz; Donald W. Landry

doi:10.1016/j.bmcl.2008.03.079

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

Yuli Xie, Yidong Liu, Gangli Gong, Alison Rinderspacher, Shi Xian Deng, Deborah H. Smith, Udo Toebben, Effie Tzilianos, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Lutz Tautz, Donald W. Landry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.

Original language	English (US)
Pages (from-to)	2840-2844
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2008.03.079
State	Published - May 1 2008
Externally published	Yes

Keywords

Lyp
Salicylate
Thiazolidine
pTyr mimics

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2008.03.079

Cite this

Xie, Y., Liu, Y., Gong, G., Rinderspacher, A., Deng, S. X., Smith, D. H., Toebben, U., Tzilianos, E., Branden, L., Vidović, D., Chung, C., Schürer, S., Tautz, L., & Landry, D. W. (2008). Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase. Bioorganic and Medicinal Chemistry Letters, 18(9), 2840-2844. https://doi.org/10.1016/j.bmcl.2008.03.079

Xie, Y, Liu, Y, Gong, G, Rinderspacher, A, Deng, SX, Smith, DH, Toebben, U, Tzilianos, E, Branden, L, Vidović, D, Chung, C, Schürer, S, Tautz, L & Landry, DW 2008, 'Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase', Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 9, pp. 2840-2844. https://doi.org/10.1016/j.bmcl.2008.03.079

@article{4fa5f98336de47c6aab0a579ebfd4da4,

title = "Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase",

abstract = "We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.",

keywords = "Lyp, Salicylate, Thiazolidine, pTyr mimics",

author = "Yuli Xie and Yidong Liu and Gangli Gong and Alison Rinderspacher and Deng, {Shi Xian} and Smith, {Deborah H.} and Udo Toebben and Effie Tzilianos and Lars Branden and Du{\v s}ica Vidovi{\'c} and Caty Chung and Stephan Sch{\"u}rer and Lutz Tautz and Landry, {Donald W.}",

year = "2008",

month = may,

day = "1",

doi = "10.1016/j.bmcl.2008.03.079",

language = "English (US)",

volume = "18",

pages = "2840--2844",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

AU - Xie, Yuli

AU - Liu, Yidong

AU - Gong, Gangli

AU - Rinderspacher, Alison

AU - Deng, Shi Xian

AU - Smith, Deborah H.

AU - Toebben, Udo

AU - Tzilianos, Effie

AU - Branden, Lars

AU - Vidović, Dušica

AU - Chung, Caty

AU - Schürer, Stephan

AU - Tautz, Lutz

AU - Landry, Donald W.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.

AB - We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.

KW - Lyp

KW - Salicylate

KW - Thiazolidine

KW - pTyr mimics

UR - http://www.scopus.com/inward/record.url?scp=42949146123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949146123&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2008.03.079

DO - 10.1016/j.bmcl.2008.03.079

M3 - Article

C2 - 18434147

AN - SCOPUS:42949146123

SN - 0960-894X

VL - 18

SP - 2840

EP - 2844

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this