Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome

Farhad Sahebjam, Cristina H. Hajdu, Esther Nortey, Samuel H. Sigal

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.

Original languageEnglish (US)
Pages (from-to)632-636
Number of pages5
JournalWorld Journal of Hepatology
Volume8
Issue number14
DOIs
StatePublished - May 18 2016

Keywords

  • Autoimmune hepatitis
  • Direct acting antiviral therapy
  • Hepatitis C
  • Overlap syndrome

ASJC Scopus subject areas

  • Hepatology

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