Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome

Farhad Sahebjam; Cristina H. Hajdu; Esther Nortey; Samuel H. Sigal

doi:10.4254/wjh.v8.i14.632

Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome

Farhad Sahebjam, Cristina H. Hajdu, Esther Nortey, Samuel H. Sigal

Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.

Original language	English (US)
Pages (from-to)	632-636
Number of pages	5
Journal	World Journal of Hepatology
Volume	8
Issue number	14
DOIs	https://doi.org/10.4254/wjh.v8.i14.632
State	Published - May 18 2016

Keywords

Autoimmune hepatitis
Direct acting antiviral therapy
Hepatitis C
Overlap syndrome

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4254/wjh.v8.i14.632

Cite this

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title = "Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome",

abstract = "Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.",

keywords = "Autoimmune hepatitis, Direct acting antiviral therapy, Hepatitis C, Overlap syndrome",

author = "Farhad Sahebjam and Hajdu, {Cristina H.} and Esther Nortey and Sigal, {Samuel H.}",

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T1 - Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome

AU - Sahebjam, Farhad

AU - Hajdu, Cristina H.

AU - Nortey, Esther

AU - Sigal, Samuel H.

N1 - Publisher Copyright: © The Author(s) 2016.

PY - 2016/5/18

Y1 - 2016/5/18

N2 - Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.

AB - Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.

KW - Autoimmune hepatitis

KW - Direct acting antiviral therapy

KW - Hepatitis C

KW - Overlap syndrome

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JF - World Journal of Hepatology

IS - 14

ER -

Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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