Differential impairment of auditory and contextual fear conditioning by protein synthesis inhibition in C57BL/6N mice

Oliver Stiedl, Markki Palve, Jelena Radulovic, Karin Birkenfeld, Joachim Spiess

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A 1-trial fear conditioning was used to investigate the temporal development of fear responses expressed as increase of freezing or heart rate and its impairment by the protein synthesis inhibitor cycloheximide (CHX) in male C57BL/6N mice. Heart rate was measured with an implanted transmitter. In the memory tests, mice were exposed to tone and context provided either as foreground or background stimulus during training. The fear responses developed differently from 0 to 24 hr after training under these 3 conditions. A single pretraining CHX injection impaired both memory forms, whereas a single posttraining CHX injection impaired tone- but not context- dependent memory, with the context provided as background stimulus. It was concluded that consolidation of tone-, foreground context-, and background context-dependent fear conditioning may be mediated by partly different neuronal or partly different biochemical pathways, or both.

Original languageEnglish (US)
Pages (from-to)496-506
Number of pages11
JournalBehavioral Neuroscience
Volume113
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience

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