Differential expression of SKI oncogene protein in hemangiomas

Teresa M. O, Melin Tan-Geller, Mark Tarango, Lou Fink, Martin Mihm, Yupo Ma, Milton Waner

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: The pathogenesis for benign tumorigenesis in hemangiomas is unknown. Oncogene proteins may be influential in this process. SKI proteins have been previously described in various malignancies. We investigated the differential expression of the SKI (sarcoma viral oncogene) protein in hemangiomas. Study Design: Prospective basic science study. Subjects and Methods: Paraffin-embedded hemangioma tissues were obtained from the senior author from 2005 to 2006. We created the first vascular tissue array composed of 12 hemangioma specimens at various stages of growth and anatomic location. Two cores were taken from each sample. Controls were also included. Immunohistochemical studies were performed using SKI, CD31, and Ki67. Results: All 12 hemangioma tissues overexpressed the SKI protein. The staining pattern was perinuclear within the endothelial cells. The intensity of staining was inversely proportional to the growth stage. The endothelial cells that were SKI-positive were involved in active cell division. Conclusion: SKI oncogene protein is differentially and specifically expressed in hemangioma tissues. SKI acts as a transcriptional co-repressor and inhibits the TGF-β pathway, thus leading to uncontrolled cellular proliferation and transformation. All vascular controls were negative for SKI staining. Clinical Significance of Study: The SKI oncogene protein is upregulated by hemangiomas and may play a role in hemangioma tumorigenesis.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume141
Issue number2
DOIs
StatePublished - Aug 2009
Externally publishedYes

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Oncogene Proteins
Hemangioma
Viral Oncogene Proteins
Blood Vessels
Carcinogenesis
Endothelial Cells
Staining and Labeling
Negative Staining
Co-Repressor Proteins
Growth
Sarcoma
Cell Division
Paraffin
Proteins
Cell Proliferation
Prospective Studies

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Differential expression of SKI oncogene protein in hemangiomas. / O, Teresa M.; Tan-Geller, Melin; Tarango, Mark; Fink, Lou; Mihm, Martin; Ma, Yupo; Waner, Milton.

In: Otolaryngology - Head and Neck Surgery, Vol. 141, No. 2, 08.2009, p. 213-218.

Research output: Contribution to journalArticle

O, Teresa M. ; Tan-Geller, Melin ; Tarango, Mark ; Fink, Lou ; Mihm, Martin ; Ma, Yupo ; Waner, Milton. / Differential expression of SKI oncogene protein in hemangiomas. In: Otolaryngology - Head and Neck Surgery. 2009 ; Vol. 141, No. 2. pp. 213-218.
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