Differential effects of cytolytic T cell subsets on intracellular infection

Steffen Stenger, Richard J. Mazzaccaro, Koichi Uyemura, Sungae Cho, Peter F. Barnes, Jean Pierre Rosat, Alessandro Sette, Michael B. Brenner, Steven A. Porcelli, Barry R. Bloom, Robert L. Modlin

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Abstract

In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4-CD8- (double-negative) T cells and CD8+ T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4-CD8- T cells was mediated by Fas-FasL interaction and had no effect on the viability of the mycobacteria. The CD8+ T cells lysed infected macrophages by a Fas-independent, granule-dependent mechanism that resulted in killing of bacteria. These data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.

Original languageEnglish (US)
Pages (from-to)1684-1687
Number of pages4
JournalScience
Volume276
Issue number5319
DOIs
StatePublished - Jun 13 1997
Externally publishedYes

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Stenger, S., Mazzaccaro, R. J., Uyemura, K., Cho, S., Barnes, P. F., Rosat, J. P., Sette, A., Brenner, M. B., Porcelli, S. A., Bloom, B. R., & Modlin, R. L. (1997). Differential effects of cytolytic T cell subsets on intracellular infection. Science, 276(5319), 1684-1687. https://doi.org/10.1126/science.276.5319.1684