Differential cadherin expression: Potential markers for epithelial to mesenchymal transformation during tumor progression

Georgia Agiostratidou, James Hulit, Greg R. Phillips, Rachel B. Hazan

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The cadherin family of adhesion molecules regulates cell-cell interactions during development and in tissues. The prototypical cadherin, E-cadherin, is responsible for maintaining interactions of epithelial cells and is frequently downregulated during tumor progression. N-cadherin, normally found in fibroblasts and neural cells, can be upregulated during tumor progression and can increase the invasiveness of tumor cells. The proinvasive effects of N-cadherin expression in tumor cells result from two possible mechanisms: promotion of tumor cell interactions with the N-cadherin-expressing microenvironment, or enhancement of signaling via the fibroblast growth factor receptor. The downregulation of E-cadherin and the upregulation of N-cadherin in tumors may be a result of an epithelial to mesenchymal transformation (EMT) of tumor cells, which is notoriously difficult to detect in vivo. Double labeling of individual tumors with specific E- and N-cadherin antibodies suggests that EMT can occur heterogeneously and/or transiently within an invasive tumor.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalJournal of Mammary Gland Biology and Neoplasia
Volume12
Issue number2-3
DOIs
Publication statusPublished - Sep 1 2007

    Fingerprint

Keywords

  • Adhesion
  • Breast cancer
  • Invasion
  • Metastasis
  • Signaling

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this