Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism

Aditi Jatkar, Irwin J. Kurland, Stefan Judex

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls. These differences in bone were accompanied by twofold greater abdominal fat content and fourfold greater plasma leptin concentrations. High-fat feeding caused a decrease in de-novo lipid synthesis in the liver, kidney, white adipose and brown adipose tissue. In contrast to HF, the fructose diet did not significantly impact bone quantity or architecture. Fructose consumption also did not significantly alter leptin levels or de-novo lipid synthesis but reduced epididymal adipose tissue and increased brown adipose tissue. Cortical stiffness was lower in the CH than in HF mice. There were no differences in glucose or insulin levels between groups. Together, a diet high in fat had a negative influence on bone structure, adipose tissue deposition and lipid synthesis, changes that were largely avoided with a fructose-enriched diet.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCalcified Tissue International
DOIs
StateAccepted/In press - Nov 10 2016

Fingerprint

High Fat Diet
Fructose
Lipid Metabolism
Fats
Bone and Bones
Health
Brown Adipose Tissue
Carbohydrates
Leptin
Lipids
Adipose Tissue
Diet
Abdominal Fat
Weight-Bearing
Femur
Osteoporosis
Obesity
Insulin
Kidney
Glucose

Keywords

  • Cortical bone
  • Fructose
  • High-fat diet
  • Lipid synthesis
  • Trabecular bone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism. / Jatkar, Aditi; Kurland, Irwin J.; Judex, Stefan.

In: Calcified Tissue International, 10.11.2016, p. 1-9.

Research output: Contribution to journalArticle

@article{02bcc78fd155427db281c02d1a1f7083,
title = "Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism",
abstract = "Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls. These differences in bone were accompanied by twofold greater abdominal fat content and fourfold greater plasma leptin concentrations. High-fat feeding caused a decrease in de-novo lipid synthesis in the liver, kidney, white adipose and brown adipose tissue. In contrast to HF, the fructose diet did not significantly impact bone quantity or architecture. Fructose consumption also did not significantly alter leptin levels or de-novo lipid synthesis but reduced epididymal adipose tissue and increased brown adipose tissue. Cortical stiffness was lower in the CH than in HF mice. There were no differences in glucose or insulin levels between groups. Together, a diet high in fat had a negative influence on bone structure, adipose tissue deposition and lipid synthesis, changes that were largely avoided with a fructose-enriched diet.",
keywords = "Cortical bone, Fructose, High-fat diet, Lipid synthesis, Trabecular bone",
author = "Aditi Jatkar and Kurland, {Irwin J.} and Stefan Judex",
year = "2016",
month = "11",
day = "10",
doi = "10.1007/s00223-016-0205-8",
language = "English (US)",
pages = "1--9",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",

}

TY - JOUR

T1 - Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism

AU - Jatkar, Aditi

AU - Kurland, Irwin J.

AU - Judex, Stefan

PY - 2016/11/10

Y1 - 2016/11/10

N2 - Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls. These differences in bone were accompanied by twofold greater abdominal fat content and fourfold greater plasma leptin concentrations. High-fat feeding caused a decrease in de-novo lipid synthesis in the liver, kidney, white adipose and brown adipose tissue. In contrast to HF, the fructose diet did not significantly impact bone quantity or architecture. Fructose consumption also did not significantly alter leptin levels or de-novo lipid synthesis but reduced epididymal adipose tissue and increased brown adipose tissue. Cortical stiffness was lower in the CH than in HF mice. There were no differences in glucose or insulin levels between groups. Together, a diet high in fat had a negative influence on bone structure, adipose tissue deposition and lipid synthesis, changes that were largely avoided with a fructose-enriched diet.

AB - Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls. These differences in bone were accompanied by twofold greater abdominal fat content and fourfold greater plasma leptin concentrations. High-fat feeding caused a decrease in de-novo lipid synthesis in the liver, kidney, white adipose and brown adipose tissue. In contrast to HF, the fructose diet did not significantly impact bone quantity or architecture. Fructose consumption also did not significantly alter leptin levels or de-novo lipid synthesis but reduced epididymal adipose tissue and increased brown adipose tissue. Cortical stiffness was lower in the CH than in HF mice. There were no differences in glucose or insulin levels between groups. Together, a diet high in fat had a negative influence on bone structure, adipose tissue deposition and lipid synthesis, changes that were largely avoided with a fructose-enriched diet.

KW - Cortical bone

KW - Fructose

KW - High-fat diet

KW - Lipid synthesis

KW - Trabecular bone

UR - http://www.scopus.com/inward/record.url?scp=84994796733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994796733&partnerID=8YFLogxK

U2 - 10.1007/s00223-016-0205-8

DO - 10.1007/s00223-016-0205-8

M3 - Article

C2 - 27832314

AN - SCOPUS:84994796733

SP - 1

EP - 9

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

ER -