Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative

James M. Shikany, David T. Redden, Marian L. Neuhouser, Rowan T. Chlebowski, Thomas E. Rohan, Michael S. Simon, Simin Liu, Dorothy S. Lane, Lesley Tinker

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Abstract

Dietary glycemic load (GL), glycemic index (GI), and carbohydrate could be associated with breast cancer risk by influencing long-term blood glucose and insulin concentrations. We examined associations between GL, GI, and carbohydrate and incident breast cancer in 148,767 Women's Heath Initiative (WHI) participants. Dietary variables were estimated from food frequency questionnaires administered at baseline. Self-reported breast cancers during follow-up were confirmed by medical records review. Cox proportional hazards regression modeled time to breast cancer within quintiles of GL, GI, and carbohydrate. There were 6,115 total breast cancers after a median follow-up of 8.0 yr. We observed no associations between GL, GI, or carbohydrate and total incident breast cancer, with hazard ratios and 95% confidence intervals for the highest vs. lowest quintiles of 1.08, 0.92-1.29 (P for trend = 0.27); 1.01, 0.91-1.12 (P = 0.74); and 0.95, 0.80-1.14 (P = 0.98), respectively. There was a trend toward significance for the positive association between GL and in situ cancers (1.40, 0.94-2.13; P = 0.07). Although there was no evidence of associations between GL, GI, or carbohydrate and total breast cancer risk in WHI participants, the suggestion of an association between GL and risk of in situ cancers requires further investigation.

Original languageEnglish (US)
Pages (from-to)899-907
Number of pages9
JournalNutrition and Cancer
Volume63
Issue number6
DOIs
StatePublished - Aug 2011

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Glycemic Index
Women's Health
Carbohydrates
Breast Neoplasms
Glycemic Load
Medical Records
Blood Glucose
Neoplasms
Confidence Intervals
Insulin
Food

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative. / Shikany, James M.; Redden, David T.; Neuhouser, Marian L.; Chlebowski, Rowan T.; Rohan, Thomas E.; Simon, Michael S.; Liu, Simin; Lane, Dorothy S.; Tinker, Lesley.

In: Nutrition and Cancer, Vol. 63, No. 6, 08.2011, p. 899-907.

Research output: Contribution to journalArticle

Shikany, JM, Redden, DT, Neuhouser, ML, Chlebowski, RT, Rohan, TE, Simon, MS, Liu, S, Lane, DS & Tinker, L 2011, 'Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative', Nutrition and Cancer, vol. 63, no. 6, pp. 899-907. https://doi.org/10.1080/01635581.2011.587227
Shikany, James M. ; Redden, David T. ; Neuhouser, Marian L. ; Chlebowski, Rowan T. ; Rohan, Thomas E. ; Simon, Michael S. ; Liu, Simin ; Lane, Dorothy S. ; Tinker, Lesley. / Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative. In: Nutrition and Cancer. 2011 ; Vol. 63, No. 6. pp. 899-907.
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