Dietary carotenoids and risk of breast cancer

Paul Terry, Meera Jain, Anthony B. Miller, Geoffrey R. Howe, Thomas E. Rohan

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: Many studies of fruit and vegetable consumption showed inverse associations with breast cancer risk, suggesting the potential importance of carotenoids (and other phytochemicals) contained in these foods. To date, however, only one prospective cohort study has examined dietary carotenoids other than β-carotene in relation to breast cancer risk. Objective: Our aim was to examine the relations between dietary intakes of β-carotene, α-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin and breast cancer risk in a large cohort study of Canadian women. Design: A case-cohort analysis was undertaken in a cohort of 56 837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993 a total of 1589 women were diagnosed with biopsy-confirmed incident breast cancer. For comparison, a subcohort of 5681 women was randomly selected. After exclusions for various reasons, the analyses were based on 1452 cases and 5239 noncases. Results: We found no clear association between intakes of any of the studied carotenoids and breast cancer risk in the study population as a whole or in subgroups defined by smoking status; relative body weight (assessed by body mass index); intakes of total fat, energy, alcohol, or folic acid; family history of breast cancer; or menopausal status. Conclusions: Our data do not support any association between dietary intakes of the studied carotenoids and breast cancer risk. However, prospective cohort studies of carotenoids in relation to breast cancer are scarce and further studies are warranted.

Original languageEnglish (US)
Pages (from-to)883-888
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume76
Issue number4
StatePublished - Oct 2002

Fingerprint

Carotenoids
breast neoplasms
carotenoids
Breast Neoplasms
Cohort Studies
carotenes
cohort studies
food intake
Prospective Studies
cultural heritage
Lutein
menopause
smoking (food products)
vegetable consumption
zeaxanthin
fruit consumption
Phytochemicals
lycopene
lutein
Folic Acid

Keywords

  • β-carotene
  • Breast neoplasms
  • Canadian National Breast Screening Study
  • Carotenoids
  • Cohort studies
  • Diet
  • Women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Terry, P., Jain, M., Miller, A. B., Howe, G. R., & Rohan, T. E. (2002). Dietary carotenoids and risk of breast cancer. American Journal of Clinical Nutrition, 76(4), 883-888.

Dietary carotenoids and risk of breast cancer. / Terry, Paul; Jain, Meera; Miller, Anthony B.; Howe, Geoffrey R.; Rohan, Thomas E.

In: American Journal of Clinical Nutrition, Vol. 76, No. 4, 10.2002, p. 883-888.

Research output: Contribution to journalArticle

Terry, P, Jain, M, Miller, AB, Howe, GR & Rohan, TE 2002, 'Dietary carotenoids and risk of breast cancer', American Journal of Clinical Nutrition, vol. 76, no. 4, pp. 883-888.
Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary carotenoids and risk of breast cancer. American Journal of Clinical Nutrition. 2002 Oct;76(4):883-888.
Terry, Paul ; Jain, Meera ; Miller, Anthony B. ; Howe, Geoffrey R. ; Rohan, Thomas E. / Dietary carotenoids and risk of breast cancer. In: American Journal of Clinical Nutrition. 2002 ; Vol. 76, No. 4. pp. 883-888.
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