TY - JOUR
T1 - Diet quality, inflammation, and the ankle brachial index in adults with or without cardiometabolic conditions
AU - Mattei, Josiemer
AU - Sotres-Alvarez, Daniela
AU - Gellman, Marc
AU - Castañeda, Sheila F.
AU - Hu, Frank B.
AU - Tucker, Katherine L.
AU - Siega-Riz, Anna Maria
AU - Kaplan, Robert C.
N1 - Funding Information:
This analysis was funded by a Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research ( K01-HL120951 ) from the NIH-National Heart Lung and Blood Institute ( NHLBI ). The Hispanic Community Health Study/Study of Hispanics/Latinos/Latinos was carried out as a collaborative study supported by contracts from the NHLBI to the University of North Carolina ( N01-HC65233 ), University of Miami ( N01-HC65234 ), Albert Einstein College of Medicine ( N01-HC65235 ), Northwestern University ( N01-HC65236 ), and San Diego State University ( N01-HC65237 ). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities , the National Institute on Deafness and Other Communication Disorders , the National Institute of Dental and Craniofacial Research , the National Institute of Diabetes and Digestive and Kidney Diseases , the National Institute of Neurological Disorders and Stroke , and the Office of Dietary Supplements . The funding agencies had no role in the preparation of this article.
PY - 2018/8
Y1 - 2018/8
N2 - Background & aims: Diet quality may influence non-traditional cardiovascular disease (CVD) risk factors – namely, C-reactive protein (CRP) and the ankle-brachial index (ABI). Pre-existing traditional cardiometabolic conditions may confound this association. We aimed to determine whether diet quality was associated with high-risk CRP or ABI, independently from traditional cardiometabolic risk factors. Methods: Baseline data were analyzed from US-Hispanics/Latinos aged 18–74 y without previously-diagnosed CVD participating in the population-based Hispanic Community Health Study/Study of Latinos cohort. Included were 14,623 participants with CRP data, and 7892 participants (≥45 y) with ABI data. Diet quality was measured with the Alternate Healthy Eating Index (AHEI). Results: Nearly 35% of Hispanics/Latinos had high-risk CRP concentration and 6.3% had high-risk ABI (peripheral artery disease (PAD): 4.2%; arterial stiffness: 2.1%). After adjusting for sociodemographic and lifestyle factors, diabetes, hypertension, hypercholesterolemia, and obesity, the odds (95% confidence interval) of having high-risk ABI were 37% (5, 44%) lower per 10-unit increase in AHEI (p = 0.018). The association was marginally significant for PAD (0.77 (0.58, 1.00); p = 0.05), and non-significant for arterial stiffness (p = 0.16). Each 10-unit increase in AHEI was associated with 21% (10, 30%) lower odds of high-risk CRP (p = 0.0002) after similar adjustments. There were no significant interactions between AHEI and age, sex, ethnicity, smoking, or pre-existing cardiometabolic conditions for associations with ABI. The association between AHEI and high-risk CRP was stronger for those with diabetes (p-interaction < 0.0001), obesity (p-interaction = 0.005), or ages 45–74 y (p-interaction = 0.011). Conclusions: Higher diet quality is associated with lower inflammation and less adverse ABI among Hispanics/Latinos, independently from traditional cardiometabolic risk factors.
AB - Background & aims: Diet quality may influence non-traditional cardiovascular disease (CVD) risk factors – namely, C-reactive protein (CRP) and the ankle-brachial index (ABI). Pre-existing traditional cardiometabolic conditions may confound this association. We aimed to determine whether diet quality was associated with high-risk CRP or ABI, independently from traditional cardiometabolic risk factors. Methods: Baseline data were analyzed from US-Hispanics/Latinos aged 18–74 y without previously-diagnosed CVD participating in the population-based Hispanic Community Health Study/Study of Latinos cohort. Included were 14,623 participants with CRP data, and 7892 participants (≥45 y) with ABI data. Diet quality was measured with the Alternate Healthy Eating Index (AHEI). Results: Nearly 35% of Hispanics/Latinos had high-risk CRP concentration and 6.3% had high-risk ABI (peripheral artery disease (PAD): 4.2%; arterial stiffness: 2.1%). After adjusting for sociodemographic and lifestyle factors, diabetes, hypertension, hypercholesterolemia, and obesity, the odds (95% confidence interval) of having high-risk ABI were 37% (5, 44%) lower per 10-unit increase in AHEI (p = 0.018). The association was marginally significant for PAD (0.77 (0.58, 1.00); p = 0.05), and non-significant for arterial stiffness (p = 0.16). Each 10-unit increase in AHEI was associated with 21% (10, 30%) lower odds of high-risk CRP (p = 0.0002) after similar adjustments. There were no significant interactions between AHEI and age, sex, ethnicity, smoking, or pre-existing cardiometabolic conditions for associations with ABI. The association between AHEI and high-risk CRP was stronger for those with diabetes (p-interaction < 0.0001), obesity (p-interaction = 0.005), or ages 45–74 y (p-interaction = 0.011). Conclusions: Higher diet quality is associated with lower inflammation and less adverse ABI among Hispanics/Latinos, independently from traditional cardiometabolic risk factors.
KW - Ankle brachial blood pressure index
KW - Diet quality
KW - HCHS/SOL
KW - Inflammation
KW - Peripheral arterial disease
KW - Subclinical vascular disease
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U2 - 10.1016/j.clnu.2017.06.003
DO - 10.1016/j.clnu.2017.06.003
M3 - Article
C2 - 28666597
AN - SCOPUS:85021815795
VL - 37
SP - 1332
EP - 1339
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 4
ER -