In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health