Diazepam in the management of heroin withdrawal in adolescents: Preliminary report

Iris F. Litt, Anita S. Colli, Michael I. Cohen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.

Original languageEnglish (US)
Pages (from-to)692-696
Number of pages5
JournalThe Journal of Pediatrics
Volume78
Issue number4
DOIs
StatePublished - 1971

Fingerprint

Heroin
Diazepam
Opiate Alkaloids
Substance Withdrawal Syndrome
Morphine
Clinical Trials

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Diazepam in the management of heroin withdrawal in adolescents : Preliminary report. / Litt, Iris F.; Colli, Anita S.; Cohen, Michael I.

In: The Journal of Pediatrics, Vol. 78, No. 4, 1971, p. 692-696.

Research output: Contribution to journalArticle

@article{6a3dbc5b1c6b4fafa113cf8a49458a4a,
title = "Diazepam in the management of heroin withdrawal in adolescents: Preliminary report",
abstract = "In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.",
author = "Litt, {Iris F.} and Colli, {Anita S.} and Cohen, {Michael I.}",
year = "1971",
doi = "10.1016/S0022-3476(71)80479-1",
language = "English (US)",
volume = "78",
pages = "692--696",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Diazepam in the management of heroin withdrawal in adolescents

T2 - Preliminary report

AU - Litt, Iris F.

AU - Colli, Anita S.

AU - Cohen, Michael I.

PY - 1971

Y1 - 1971

N2 - In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.

AB - In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.

UR - http://www.scopus.com/inward/record.url?scp=0015043023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015043023&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(71)80479-1

DO - 10.1016/S0022-3476(71)80479-1

M3 - Article

C2 - 4926621

AN - SCOPUS:0015043023

VL - 78

SP - 692

EP - 696

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 4

ER -