Diastolic dysfunction: Can it be diagnosed by Doppler echocardiography?

Mathew S. Maurer, Daniel M. Spevack, Daniel Burkhoff, Itzhak Kronzon

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Heart failure with a normal ejection fraction (HFNEF) predominately afflicts older, female individuals and is considered to be a consequence of diastolic dysfunction. Doppler echocardiography has become the standard method for identifying and characterizing diastolic function. However, the important distinction between Doppler measures of filling dynamics and true indexes of intrinsic ventricular diastolic chamber properties is not widely appreciated. Herein, we delineate physiologic measures of intrinsic ventricular diastolic function, as determined by pressure volume analysis, and compare and contrast these measures with those derived from Doppler echocardiography. Doppler-derived indexes of ventricular filling do not provide specific information on intrinsic passive diastolic properties, and thus, abnormal filling dynamics do not necessarily equate with intrinsic myocardial diastolic dysfunction. This raises a fundamental question as to whether delayed relaxation and/or stiffened passive properties are the unifying pathophysiologic mechanisms in all patients who present with HFNEF.

Original languageEnglish (US)
Pages (from-to)1543-1549
Number of pages7
JournalJournal of the American College of Cardiology
Volume44
Issue number8
DOIs
StatePublished - Oct 19 2004
Externally publishedYes

Fingerprint

Doppler Echocardiography
Heart Failure
Ventricular Function
Pressure

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Diastolic dysfunction : Can it be diagnosed by Doppler echocardiography? / Maurer, Mathew S.; Spevack, Daniel M.; Burkhoff, Daniel; Kronzon, Itzhak.

In: Journal of the American College of Cardiology, Vol. 44, No. 8, 19.10.2004, p. 1543-1549.

Research output: Contribution to journalArticle

Maurer, Mathew S. ; Spevack, Daniel M. ; Burkhoff, Daniel ; Kronzon, Itzhak. / Diastolic dysfunction : Can it be diagnosed by Doppler echocardiography?. In: Journal of the American College of Cardiology. 2004 ; Vol. 44, No. 8. pp. 1543-1549.
@article{e371e62c334e41b38ded2c76c3b6fb30,
title = "Diastolic dysfunction: Can it be diagnosed by Doppler echocardiography?",
abstract = "Heart failure with a normal ejection fraction (HFNEF) predominately afflicts older, female individuals and is considered to be a consequence of diastolic dysfunction. Doppler echocardiography has become the standard method for identifying and characterizing diastolic function. However, the important distinction between Doppler measures of filling dynamics and true indexes of intrinsic ventricular diastolic chamber properties is not widely appreciated. Herein, we delineate physiologic measures of intrinsic ventricular diastolic function, as determined by pressure volume analysis, and compare and contrast these measures with those derived from Doppler echocardiography. Doppler-derived indexes of ventricular filling do not provide specific information on intrinsic passive diastolic properties, and thus, abnormal filling dynamics do not necessarily equate with intrinsic myocardial diastolic dysfunction. This raises a fundamental question as to whether delayed relaxation and/or stiffened passive properties are the unifying pathophysiologic mechanisms in all patients who present with HFNEF.",
author = "Maurer, {Mathew S.} and Spevack, {Daniel M.} and Daniel Burkhoff and Itzhak Kronzon",
year = "2004",
month = "10",
day = "19",
doi = "10.1016/j.jacc.2004.07.034",
language = "English (US)",
volume = "44",
pages = "1543--1549",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "8",

}

TY - JOUR

T1 - Diastolic dysfunction

T2 - Can it be diagnosed by Doppler echocardiography?

AU - Maurer, Mathew S.

AU - Spevack, Daniel M.

AU - Burkhoff, Daniel

AU - Kronzon, Itzhak

PY - 2004/10/19

Y1 - 2004/10/19

N2 - Heart failure with a normal ejection fraction (HFNEF) predominately afflicts older, female individuals and is considered to be a consequence of diastolic dysfunction. Doppler echocardiography has become the standard method for identifying and characterizing diastolic function. However, the important distinction between Doppler measures of filling dynamics and true indexes of intrinsic ventricular diastolic chamber properties is not widely appreciated. Herein, we delineate physiologic measures of intrinsic ventricular diastolic function, as determined by pressure volume analysis, and compare and contrast these measures with those derived from Doppler echocardiography. Doppler-derived indexes of ventricular filling do not provide specific information on intrinsic passive diastolic properties, and thus, abnormal filling dynamics do not necessarily equate with intrinsic myocardial diastolic dysfunction. This raises a fundamental question as to whether delayed relaxation and/or stiffened passive properties are the unifying pathophysiologic mechanisms in all patients who present with HFNEF.

AB - Heart failure with a normal ejection fraction (HFNEF) predominately afflicts older, female individuals and is considered to be a consequence of diastolic dysfunction. Doppler echocardiography has become the standard method for identifying and characterizing diastolic function. However, the important distinction between Doppler measures of filling dynamics and true indexes of intrinsic ventricular diastolic chamber properties is not widely appreciated. Herein, we delineate physiologic measures of intrinsic ventricular diastolic function, as determined by pressure volume analysis, and compare and contrast these measures with those derived from Doppler echocardiography. Doppler-derived indexes of ventricular filling do not provide specific information on intrinsic passive diastolic properties, and thus, abnormal filling dynamics do not necessarily equate with intrinsic myocardial diastolic dysfunction. This raises a fundamental question as to whether delayed relaxation and/or stiffened passive properties are the unifying pathophysiologic mechanisms in all patients who present with HFNEF.

UR - http://www.scopus.com/inward/record.url?scp=5644232173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5644232173&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2004.07.034

DO - 10.1016/j.jacc.2004.07.034

M3 - Article

C2 - 15489083

AN - SCOPUS:5644232173

VL - 44

SP - 1543

EP - 1549

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 8

ER -