Diagnostic yield of pelvic magnetic resonance venography in patients with cryptogenic stroke and patent foramen ovale

Ava Leigh Liberman, Vistasp J. Daruwalla, Jeremy D. Collins, Matthew B. Maas, Marcos Paulo Ferreira Botelho, Jad Bou Ayache, James Carr, Ilana Ruff, Richard A. Bernstein, Marc J. Alberts, Shyam Prabhakaran

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - : Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity and pelvic veins might be an embolic source in cryptogenic stroke (CS) patients with patent foramen ovale. METHODS - : Consecutive adult patients with ischemic stroke or transient ischemic attack and a patent foramen ovale who underwent pelvic magnetic resonance venography as part of an inpatient diagnostic evaluation were included in this single-center retrospective observational study to determine pelvic and lower extremity (LE) deep venous thrombosis (DVT) prevalence in CS versus non-CS stroke subtypes. RESULTS - : Of 131 patients who met inclusion criteria, 126 (96.2%) also had LE duplex ultrasound data. DVT prevalence overall was 7.6% (95% confidence interval, 4.1-13.6), pelvic DVT 1.5% (95% confidence interval, 0.1-5.8), and LE DVT 7.1% (95% confidence interval, 3.6-13.2). One patient with a pelvic DVT also had a LE DVT. Comparing patients with CS (n=98) with non-CS subtypes (n=33), there was no significant difference in the prevalence of pelvic DVT (2.1% versus 0%, P=1), LE DVT (6.2% versus 10.3%, P=0.43), or any DVT (7.2% versus 9.1%, P=0.71). CONCLUSIONS - : Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.

Original languageEnglish (US)
Pages (from-to)2324-2329
Number of pages6
JournalStroke
Volume45
Issue number8
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Patent Foramen Ovale
Phlebography
Magnetic Resonance Spectroscopy
Venous Thrombosis
Stroke
Lower Extremity
Veins
Transient Ischemic Attack
Confidence Intervals
Observational Studies
Inpatients
Retrospective Studies

Keywords

  • physiopathology
  • thromboembolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Liberman, A. L., Daruwalla, V. J., Collins, J. D., Maas, M. B., Botelho, M. P. F., Ayache, J. B., ... Prabhakaran, S. (2014). Diagnostic yield of pelvic magnetic resonance venography in patients with cryptogenic stroke and patent foramen ovale. Stroke, 45(8), 2324-2329. https://doi.org/10.1161/STROKEAHA.114.005539

Diagnostic yield of pelvic magnetic resonance venography in patients with cryptogenic stroke and patent foramen ovale. / Liberman, Ava Leigh; Daruwalla, Vistasp J.; Collins, Jeremy D.; Maas, Matthew B.; Botelho, Marcos Paulo Ferreira; Ayache, Jad Bou; Carr, James; Ruff, Ilana; Bernstein, Richard A.; Alberts, Marc J.; Prabhakaran, Shyam.

In: Stroke, Vol. 45, No. 8, 2014, p. 2324-2329.

Research output: Contribution to journalArticle

Liberman, AL, Daruwalla, VJ, Collins, JD, Maas, MB, Botelho, MPF, Ayache, JB, Carr, J, Ruff, I, Bernstein, RA, Alberts, MJ & Prabhakaran, S 2014, 'Diagnostic yield of pelvic magnetic resonance venography in patients with cryptogenic stroke and patent foramen ovale', Stroke, vol. 45, no. 8, pp. 2324-2329. https://doi.org/10.1161/STROKEAHA.114.005539
Liberman, Ava Leigh ; Daruwalla, Vistasp J. ; Collins, Jeremy D. ; Maas, Matthew B. ; Botelho, Marcos Paulo Ferreira ; Ayache, Jad Bou ; Carr, James ; Ruff, Ilana ; Bernstein, Richard A. ; Alberts, Marc J. ; Prabhakaran, Shyam. / Diagnostic yield of pelvic magnetic resonance venography in patients with cryptogenic stroke and patent foramen ovale. In: Stroke. 2014 ; Vol. 45, No. 8. pp. 2324-2329.
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abstract = "BACKGROUND AND PURPOSE - : Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity and pelvic veins might be an embolic source in cryptogenic stroke (CS) patients with patent foramen ovale. METHODS - : Consecutive adult patients with ischemic stroke or transient ischemic attack and a patent foramen ovale who underwent pelvic magnetic resonance venography as part of an inpatient diagnostic evaluation were included in this single-center retrospective observational study to determine pelvic and lower extremity (LE) deep venous thrombosis (DVT) prevalence in CS versus non-CS stroke subtypes. RESULTS - : Of 131 patients who met inclusion criteria, 126 (96.2{\%}) also had LE duplex ultrasound data. DVT prevalence overall was 7.6{\%} (95{\%} confidence interval, 4.1-13.6), pelvic DVT 1.5{\%} (95{\%} confidence interval, 0.1-5.8), and LE DVT 7.1{\%} (95{\%} confidence interval, 3.6-13.2). One patient with a pelvic DVT also had a LE DVT. Comparing patients with CS (n=98) with non-CS subtypes (n=33), there was no significant difference in the prevalence of pelvic DVT (2.1{\%} versus 0{\%}, P=1), LE DVT (6.2{\%} versus 10.3{\%}, P=0.43), or any DVT (7.2{\%} versus 9.1{\%}, P=0.71). CONCLUSIONS - : Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.",
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AU - Collins, Jeremy D.

AU - Maas, Matthew B.

AU - Botelho, Marcos Paulo Ferreira

AU - Ayache, Jad Bou

AU - Carr, James

AU - Ruff, Ilana

AU - Bernstein, Richard A.

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N2 - BACKGROUND AND PURPOSE - : Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity and pelvic veins might be an embolic source in cryptogenic stroke (CS) patients with patent foramen ovale. METHODS - : Consecutive adult patients with ischemic stroke or transient ischemic attack and a patent foramen ovale who underwent pelvic magnetic resonance venography as part of an inpatient diagnostic evaluation were included in this single-center retrospective observational study to determine pelvic and lower extremity (LE) deep venous thrombosis (DVT) prevalence in CS versus non-CS stroke subtypes. RESULTS - : Of 131 patients who met inclusion criteria, 126 (96.2%) also had LE duplex ultrasound data. DVT prevalence overall was 7.6% (95% confidence interval, 4.1-13.6), pelvic DVT 1.5% (95% confidence interval, 0.1-5.8), and LE DVT 7.1% (95% confidence interval, 3.6-13.2). One patient with a pelvic DVT also had a LE DVT. Comparing patients with CS (n=98) with non-CS subtypes (n=33), there was no significant difference in the prevalence of pelvic DVT (2.1% versus 0%, P=1), LE DVT (6.2% versus 10.3%, P=0.43), or any DVT (7.2% versus 9.1%, P=0.71). CONCLUSIONS - : Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.

AB - BACKGROUND AND PURPOSE - : Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity and pelvic veins might be an embolic source in cryptogenic stroke (CS) patients with patent foramen ovale. METHODS - : Consecutive adult patients with ischemic stroke or transient ischemic attack and a patent foramen ovale who underwent pelvic magnetic resonance venography as part of an inpatient diagnostic evaluation were included in this single-center retrospective observational study to determine pelvic and lower extremity (LE) deep venous thrombosis (DVT) prevalence in CS versus non-CS stroke subtypes. RESULTS - : Of 131 patients who met inclusion criteria, 126 (96.2%) also had LE duplex ultrasound data. DVT prevalence overall was 7.6% (95% confidence interval, 4.1-13.6), pelvic DVT 1.5% (95% confidence interval, 0.1-5.8), and LE DVT 7.1% (95% confidence interval, 3.6-13.2). One patient with a pelvic DVT also had a LE DVT. Comparing patients with CS (n=98) with non-CS subtypes (n=33), there was no significant difference in the prevalence of pelvic DVT (2.1% versus 0%, P=1), LE DVT (6.2% versus 10.3%, P=0.43), or any DVT (7.2% versus 9.1%, P=0.71). CONCLUSIONS - : Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.

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