Diagnostic X-rays and risk of epithelial ovarian carcinoma in Jews

Susan Harlap, Sara H. Olson, Richard R. Barakat, Thomas A. Caputo, Silvia Forment, Allan J. Jacobs, Christine Nakraseive, Xiaonan Xue

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

PURPOSE: To test the hypothesis that there would be ethnic differences in susceptibility to ionizing radiation from diagnostic x-rays. METHODS: In a hospital-based study we compared reports of diagnostic x-rays to the lower abdomen and pelvis in incident cases of epithelial ovarian carcinoma (N = 161), community controls (N = 156) and convenience controls (N = 87). RESULTS: Thirty-nine per cent of cases and 31% of controls recalled x-rays more than 10 years before; 27% of cases and 14% of controls reported four Jewish grandparents. Comparing the cases with community controls, the odds ratio (95% confidence interval) for Jews versus non-Jews among women reporting no x-rays was 1.02 (0.37-2.79); among women reporting x-rays the estimate for Jews was 8.91 (2.00-39.6). Consistent results were seen with inclusion of convenience controls. Jewish cases reported an excess of pelvic diagnostic x-rays from age 20 onward and an excess of barium enemas and pyelograms. CONCLUSIONS: These preliminary findings require confirmation in other studies. They suggest that the known excess risk of this carcinoma in Jews might be associated with exposure to x-rays and add to a previous observation of an altered susceptibility to ionizing radiation in Jews. If confirmed, they would suggest a need for continued vigilance to evaluate the risks and benefits of diagnostic x-rays in individuals, regardless of ethnic origin, who might carry mutations in DNA repair genes.

Original languageEnglish (US)
Pages (from-to)426-434
Number of pages9
JournalAnnals of Epidemiology
Volume12
Issue number6
DOIs
StatePublished - Aug 8 2002

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Keywords

  • BRCA1/2
  • Case-Control Studies
  • DNA Repair
  • Diagnostic Radiation
  • Ethnic Groups
  • Genetic Susceptibility
  • Host Factors
  • Jews
  • Ovary Neoplasms
  • Translational Research

ASJC Scopus subject areas

  • Epidemiology

Cite this

Harlap, S., Olson, S. H., Barakat, R. R., Caputo, T. A., Forment, S., Jacobs, A. J., Nakraseive, C., & Xue, X. (2002). Diagnostic X-rays and risk of epithelial ovarian carcinoma in Jews. Annals of Epidemiology, 12(6), 426-434. https://doi.org/10.1016/S1047-2797(01)00301-5