Diagnostic laboratory immunology for talaromycosis (penicilliosis): review from the bench-top techniques to the point-of-care testing

Kritsada Pruksaphon, Akarin Intaramat, Kavi Ratanabanangkoon, Joshua D. Nosanchuk, Nongnuch Vanittanakom, Sirida Youngchim

Research output: Contribution to journalReview article

Abstract

The pathogenic fungus Talaromyces (formerly Penicillium) marneffei is a thermally dimorphic fungus that can cause disseminated infection in patients with secondary immunodeficiency syndrome, in particular in the setting of advanced HIV infection. The areas of highest incidence are in Southeast Asia, Southern China, and Indian subcontinents. Talaromycosis (formerly penicilliosis) is identified as an AIDS-defining illness, and it has recently been recognized in non–HIV-associated patients with impaired cellular-mediated immunity. Microbiological culture is the gold standard method for the diagnosis of T. marneffei infection and usually requires up to 2–4 weeks for detectable growth to occur, which may result in a delay of appropriate treatment. Immunodiagnosis has become an alternative method for confirming talaromycosis. This article reviews various immunological tests for the diagnosis of talaromycosis, including a proposed novel rapid point-of-care assay using a new T. marneffei yeast phase-specific monoclonal antibody.

Original languageEnglish (US)
Article number114959
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • Immunochromatography
  • Immunodiagnosis
  • Monoclonal antibody
  • Talaromyces (Penicillium) marneffei
  • Talaromycosis (penicilliosis) marneffei

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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