TY - JOUR
T1 - Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19
T2 - a systematic review and meta-analysis comprising 18,506 patients
AU - Palaiodimos, Leonidas
AU - Chamorro-Pareja, Natalia
AU - Karamanis, Dimitrios
AU - Li, Weijia
AU - Zavras, Phaedon D.
AU - Chang, Kai Ming
AU - Mathias, Priyanka
AU - Kokkinidis, Damianos G.
N1 - Publisher Copyright:
© 2020, Hellenic Endocrine Society.
PY - 2021/6
Y1 - 2021/6
N2 - Purpose: Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. The aim of this study was to systematically review and conduct a meta-analysis of the available observational studies reporting the effect of diabetes on mortality among hospitalized patients with COVID-19. Methods: The Medline, Embase, Google Scholar, and medRxiv databases were reviewed for identification of eligible studies. A random effects model meta-analysis was used, and I2 was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. Results: A total of 18,506 patients were included in this meta-analysis (3713 diabetics and 14,793 non-diabetics). Patients with diabetes were associated with a higher risk of death compared with patients without diabetes (OR 1.65; 95% CI 1.35–1.96; I2 77.4%). The heterogeneity was high. A study-level meta-regression analysis was performed for all the important covariates, and no significant interactions were found between the covariates and the outcome of mortality. Conclusion: This meta-analysis shows that that the likelihood of death seems to be higher in diabetic patients hospitalized with COVID-19 compared with non-diabetic patients. Further studies are needed to assess whether this association is independent or not, as well as to investigate the role of adequate glycemic control prior to infection with COVID-19.
AB - Purpose: Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. The aim of this study was to systematically review and conduct a meta-analysis of the available observational studies reporting the effect of diabetes on mortality among hospitalized patients with COVID-19. Methods: The Medline, Embase, Google Scholar, and medRxiv databases were reviewed for identification of eligible studies. A random effects model meta-analysis was used, and I2 was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. Results: A total of 18,506 patients were included in this meta-analysis (3713 diabetics and 14,793 non-diabetics). Patients with diabetes were associated with a higher risk of death compared with patients without diabetes (OR 1.65; 95% CI 1.35–1.96; I2 77.4%). The heterogeneity was high. A study-level meta-regression analysis was performed for all the important covariates, and no significant interactions were found between the covariates and the outcome of mortality. Conclusion: This meta-analysis shows that that the likelihood of death seems to be higher in diabetic patients hospitalized with COVID-19 compared with non-diabetic patients. Further studies are needed to assess whether this association is independent or not, as well as to investigate the role of adequate glycemic control prior to infection with COVID-19.
KW - COVID-19
KW - Diabetes
KW - Meta-analysis
KW - Mortality
KW - Risk factor
KW - SARS-CoV-2
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U2 - 10.1007/s42000-020-00246-2
DO - 10.1007/s42000-020-00246-2
M3 - Article
C2 - 33123973
AN - SCOPUS:85094215472
SN - 1109-3099
VL - 20
SP - 305
EP - 314
JO - Hormones
JF - Hormones
IS - 2
ER -