Diabetes insipidus after discontinuation of vasopressin infusion for septic shock

H. Rana, N. Ferguson, P. V. Dicpinigaitis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


What is known and objective: Despite widespread use of vasopressin for the treatment of septic shock, few cases of diabetes insipidus (DI) following its discontinuation have been reported. Case summary: A 54-year-old man presented with pneumonia progressing to septic shock, requiring norepinephrine and vasopressin for refractory hypotension. After clinical improvement, the patient on 3 separate occasions developed polyuria and severe hypernatremia upon discontinuation of vasopressin, with prompt recovery upon its resumption. What is new and conclusion: Occurrence of DI upon discontinuation of vasopressin infusion appears to be rare, but incidence may be underestimated due to a paucity of published reports. Actual incidence and underlying mechanism of this phenomenon remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalJournal of Clinical Pharmacy and Therapeutics
Issue number2
StatePublished - Apr 2018


  • desmopressin
  • diabetes insipidus
  • hypernatremia
  • septic shock
  • vasopressin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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