Diabetes and cardiovascular disease in older adults: Current status and future directions

Jeffrey B. Halter, Nicolas Musi, Frances Mc Farland Horne, Jill P. Crandall, Andrew Goldberg, Lawrence Harkless, William R. Hazzard, Elbert S. Huang, M. Sue Kirkman, Jorge Plutzky, Kenneth E. Schmader, Susan Zieman, Kevin P. High

Research output: Contribution to journalReview article

100 Scopus citations

Abstract

The prevalence of diabetes increases with age, driven in part by an absolute increase in incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk for cardiovascular disease, and age strongly predicts cardiovascular complications. Inflammation and oxidative stress appear to play some role in the mechanisms underlying aging, diabetes, cardiovascular disease, and other complications of diabetes. However, the mechanisms underlying the age-associated increase in risk for diabetes and diabetes-related cardiovascular disease remain poorly understood. Moreover, because of the heterogeneity of the older population, a lack of understanding of the biology of aging, and inadequate study of the effects of treatments on traditional complications and geriatric conditions associated with diabetes, no consensus exists on the optimal interventions for older diabetic adults. The Association of Specialty Professors, along with the National Institute on Aging, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, and the American Diabetes Association, held a workshop, summarized in this Perspective, to discuss current knowledge regarding diabetes and cardiovascular disease in older adults, identify gaps, and propose questions to guide future research.

Original languageEnglish (US)
Pages (from-to)2578-2589
Number of pages12
JournalDiabetes
Volume63
Issue number8
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Halter, J. B., Musi, N., Horne, F. M. F., Crandall, J. P., Goldberg, A., Harkless, L., Hazzard, W. R., Huang, E. S., Kirkman, M. S., Plutzky, J., Schmader, K. E., Zieman, S., & High, K. P. (2014). Diabetes and cardiovascular disease in older adults: Current status and future directions. Diabetes, 63(8), 2578-2589. https://doi.org/10.2337/db14-0020