Developmental switch in requirement for PKA RIIβ in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses

Yupeng Yang, Koichi Takeuchi, Alma Rodenas-Ruano, Yukihiro Takayasu, Michael V. L. Bennett, R. Suzanne Zukin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The cAMP/protein kinase A (PKA) signaling cascade is crucial for synaptic plasticity in a wide variety of species. PKA regulates Ca2+ permeation through NMDA receptors (NMDARs) and induction of NMDAR-dependent synaptic plasticity at the Schaffer collateral to CA1 pyramidal cell synapse. Whereas the role of PKA in induction of NMDAR-dependent LTP at CA1 synapses is established, the identity of PKA isoforms involved in this phenomenon is less clear. Here we report that protein synthesis-independent NMDAR-dependent LTP at the Schaffer collateral-CA1 synapse in the hippocampus is deficient, but NMDAR-dependent LTD is normal, in young (postnatal day 10 (P10)-P14) mice lacking PKA RIIβ, the PKA regulatory protein that links PKA to NMDARs at synaptic sites. In contrast, in young adult (P21-P28) mice lacking PKA RIIβ, LTP is normal and LTD is abolished. These findings indicate that distinct PKA isoforms may subserve distinct forms of synaptic plasticity and are consistent with a developmental switch in the signaling cascades required for LTP induction.

Original languageEnglish (US)
Pages (from-to)56-65
Number of pages10
JournalNeuropharmacology
Volume56
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Neuronal Plasticity
Pyramidal Cells
Cyclic AMP-Dependent Protein Kinases
N-Methyl-D-Aspartate Receptors
Synapses
Hippocampus
Protein Isoforms
Young Adult
Proteins

Keywords

  • CA1 synapses
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • NMDA receptors
  • PKA
  • PKA RIIβ knockout mice
  • PKA type II regulatory subunit
  • Synaptic plasticity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Developmental switch in requirement for PKA RIIβ in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses. / Yang, Yupeng; Takeuchi, Koichi; Rodenas-Ruano, Alma; Takayasu, Yukihiro; Bennett, Michael V. L.; Zukin, R. Suzanne.

In: Neuropharmacology, Vol. 56, No. 1, 01.2009, p. 56-65.

Research output: Contribution to journalArticle

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