Developmental seizure models

L. Velíšek, J. Velíšková, Solomon L. Moshe

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Seizures frequently occur in children. There are significant differences in the generation, expression and modification of seizures as a function of age. Animal models of epilepsy should depict these age-related differences. In this paper, we summarize the main features of generalized flurothyl, pentylenetetrazol, bicuculline and picrotoxin-induced seizures in adult and immature rats as well as the characteristics of focal seizures induced by amygdala kindling, systemic NMDA and kainic acid. Some of the models may be more advantageous for screening antiepileptic drug effects whereas other models may be more helpful in studying the basic mechanisms of epilepsy.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalThe Italian Journal of Neurological Sciences
Volume16
Issue number1-2
DOIs
StatePublished - Mar 1995

Fingerprint

Seizures
Epilepsy
Flurothyl
Picrotoxin
Pentylenetetrazole
Bicuculline
Kainic Acid
N-Methylaspartate
Amygdala
Anticonvulsants
Animal Models

Keywords

  • amygdala kindling
  • bicuculline
  • development
  • flurothyl
  • kainic acid
  • NMDA
  • pentylenetetrazol
  • picrotoxin
  • seizures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Developmental seizure models. / Velíšek, L.; Velíšková, J.; Moshe, Solomon L.

In: The Italian Journal of Neurological Sciences, Vol. 16, No. 1-2, 03.1995, p. 127-133.

Research output: Contribution to journalArticle

Velíšek, L. ; Velíšková, J. ; Moshe, Solomon L. / Developmental seizure models. In: The Italian Journal of Neurological Sciences. 1995 ; Vol. 16, No. 1-2. pp. 127-133.
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