Developmental plasticity of CNS microglia

Laura Santambrogio, S. L. Belyanskaya, F. R. Fischer, B. Cipriani, C. F. Brosnan, P. Ricciardi-Castagnoli, L. J. Stern, J. L. Strominger, R. Riese

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

Microglia arise from CD45+ bone marrow precursors that colonize the fetal brain and play a key role in central nervous system inflammatory conditions. We report that parenchymal microglia are uncommitted myeloid progenitors of immature dendritic cells and macrophages by several criteria, including surface expression of "empty" class II MHC protein and their cysteine protease (cathepsin) profile. Microglia express receptors for stem cell factor and can be skewed toward more dendritic cell or macrophage-like profiles in response to the lineage growth factors granulocyte/ macrophage colony-stimulating factor or macrophage colonystimulating factor. Thus, in contrast to other organs, where terminally differentiated populations of resident dendritic cells and/ or macrophages outnumber colonizing precursors, the majority of microglia within the brain remain in an undifferentiated state.

Original languageEnglish (US)
Pages (from-to)6295-6300
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number11
DOIs
StatePublished - May 22 2001
Externally publishedYes

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Microglia
Macrophages
Dendritic Cells
Proto-Oncogene Proteins c-kit
Cathepsins
Cysteine Proteases
Brain
Granulocyte-Macrophage Colony-Stimulating Factor
Intercellular Signaling Peptides and Proteins
Central Nervous System
Bone Marrow
Population
Proteins

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Santambrogio, L., Belyanskaya, S. L., Fischer, F. R., Cipriani, B., Brosnan, C. F., Ricciardi-Castagnoli, P., ... Riese, R. (2001). Developmental plasticity of CNS microglia. Proceedings of the National Academy of Sciences of the United States of America, 98(11), 6295-6300. https://doi.org/10.1073/pnas.111152498

Developmental plasticity of CNS microglia. / Santambrogio, Laura; Belyanskaya, S. L.; Fischer, F. R.; Cipriani, B.; Brosnan, C. F.; Ricciardi-Castagnoli, P.; Stern, L. J.; Strominger, J. L.; Riese, R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 11, 22.05.2001, p. 6295-6300.

Research output: Contribution to journalArticle

Santambrogio, L, Belyanskaya, SL, Fischer, FR, Cipriani, B, Brosnan, CF, Ricciardi-Castagnoli, P, Stern, LJ, Strominger, JL & Riese, R 2001, 'Developmental plasticity of CNS microglia', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 11, pp. 6295-6300. https://doi.org/10.1073/pnas.111152498
Santambrogio L, Belyanskaya SL, Fischer FR, Cipriani B, Brosnan CF, Ricciardi-Castagnoli P et al. Developmental plasticity of CNS microglia. Proceedings of the National Academy of Sciences of the United States of America. 2001 May 22;98(11):6295-6300. https://doi.org/10.1073/pnas.111152498
Santambrogio, Laura ; Belyanskaya, S. L. ; Fischer, F. R. ; Cipriani, B. ; Brosnan, C. F. ; Ricciardi-Castagnoli, P. ; Stern, L. J. ; Strominger, J. L. ; Riese, R. / Developmental plasticity of CNS microglia. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 11. pp. 6295-6300.
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