Developmental Neurotoxicity of Lead

Samuel Caito; Michael Aschner

doi:10.1007/978-3-319-60189-2_1

Developmental Neurotoxicity of Lead

Samuel Caito, Michael Aschner

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

42 Scopus citations

Abstract

Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit hyperactivity disorder. In this review, we will discuss sources of developmental lead exposure and mechanisms of lead neurotoxicity. We will highlight both human epidemiological studies showing associations between lead exposure and behavioral abnormalities as well as experimental data from animal studies. Finally, we will discuss the effects of lead on neurological endpoint past childhood, namely, development of Alzheimer’s disease in old age.

Original language	English (US)
Title of host publication	Advances in Neurobiology
Publisher	Springer New York LLC
Pages	3-12
Number of pages	10
Volume	18
DOIs	https://doi.org/10.1007/978-3-319-60189-2_1
State	Published - 2017

Publication series

Name	Advances in Neurobiology
Volume	18
ISSN (Print)	2190-5215

Keywords

Air quality criteria
Alzheimer’s disease
Behavioral impairments
Encephalopathy
Metalloproteins
Permissible exposure limit (PEL)

ASJC Scopus subject areas

Biochemistry
Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-60189-2_1

Cite this

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AU - Aschner, Michael

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AB - Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit hyperactivity disorder. In this review, we will discuss sources of developmental lead exposure and mechanisms of lead neurotoxicity. We will highlight both human epidemiological studies showing associations between lead exposure and behavioral abnormalities as well as experimental data from animal studies. Finally, we will discuss the effects of lead on neurological endpoint past childhood, namely, development of Alzheimer’s disease in old age.

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KW - Alzheimer’s disease

KW - Behavioral impairments

KW - Encephalopathy

KW - Metalloproteins

KW - Permissible exposure limit (PEL)

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Developmental Neurotoxicity of Lead

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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