Developmental Neuropathology of Environmental Agents

Lucio G. Costa, Michael Aschner, Annabella Vitalone, Tore Syversen, Offie Porat Soldin

Research output: Contribution to journalReview article

224 Scopus citations

Abstract

The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimental models as well as humans, to cause morphological changes in the developing nervous system. Chemicals that are discussed include methylmercury (MeHg), lead (Pb), antiepileptic drugs, and ethanol. Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed.

Original languageEnglish (US)
Pages (from-to)87-110
Number of pages24
JournalAnnual Review of Pharmacology and Toxicology
Volume44
DOIs
StatePublished - 2004
Externally publishedYes

Keywords

  • Antiepileptic drugs
  • Developmental neurotoxicity
  • Ethanol
  • Lead
  • Methylmercury

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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