TY - JOUR
T1 - Developmental Neuropathology of Environmental Agents
AU - Costa, Lucio G.
AU - Aschner, Michael
AU - Vitalone, Annabella
AU - Syversen, Tore
AU - Soldin, Offie Porat
PY - 2004
Y1 - 2004
N2 - The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimental models as well as humans, to cause morphological changes in the developing nervous system. Chemicals that are discussed include methylmercury (MeHg), lead (Pb), antiepileptic drugs, and ethanol. Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed.
AB - The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimental models as well as humans, to cause morphological changes in the developing nervous system. Chemicals that are discussed include methylmercury (MeHg), lead (Pb), antiepileptic drugs, and ethanol. Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed.
KW - Antiepileptic drugs
KW - Developmental neurotoxicity
KW - Ethanol
KW - Lead
KW - Methylmercury
UR - http://www.scopus.com/inward/record.url?scp=1342302419&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1342302419&partnerID=8YFLogxK
U2 - 10.1146/annurev.pharmtox.44.101802.121424
DO - 10.1146/annurev.pharmtox.44.101802.121424
M3 - Review article
C2 - 14744240
AN - SCOPUS:1342302419
SN - 0362-1642
VL - 44
SP - 87
EP - 110
JO - Annual Review of Pharmacology and Toxicology
JF - Annual Review of Pharmacology and Toxicology
ER -