Developmental aspects of status epilepticus

E. F. Sperber, K. Z. Haas, S. L. Moshe

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

It has been suggested that mesial temporal sclerosis and temporal lobe epilepsy are a consequence of seizure induced damage in early life. However, evidence of seizure induced damage in children is inconclusive. In the present report, we address the question of whether seizures produce age- related changes in the hippocampus by using animal models. Seizures were induced in pups and adult rats by kainic acid, flurothyl or kindling. Hippocampal damage was determined neuroanatomically by assessing cell loss and mossy fiber sprouting and electrophysiologically by the in vitro slice preparation. Our results indicate that seizures result in hippocampal damage in adult rats but not in developing rats. Several possible explanations for the greater resistance to seizure-induced hippocampal damage in immature rats are discussed.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalInternational Pediatrics
Volume7
Issue number3
Publication statusPublished - Jan 1 1992
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this