It has been suggested that mesial temporal sclerosis and temporal lobe epilepsy are a consequence of seizure induced damage in early life. However, evidence of seizure induced damage in children is inconclusive. In the present report, we address the question of whether seizures produce age- related changes in the hippocampus by using animal models. Seizures were induced in pups and adult rats by kainic acid, flurothyl or kindling. Hippocampal damage was determined neuroanatomically by assessing cell loss and mossy fiber sprouting and electrophysiologically by the in vitro slice preparation. Our results indicate that seizures result in hippocampal damage in adult rats but not in developing rats. Several possible explanations for the greater resistance to seizure-induced hippocampal damage in immature rats are discussed.
|Original language||English (US)|
|Number of pages||10|
|Publication status||Published - Jan 1 1992|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health