Abstract
The NANIVID - or Nano Intravital Device - is an implantable delivery tool designed to locally affect the tumor microenvironment in vivo. This technology is being redesigned and validated as a cell collection tool for the study of metastatic cancer cells. A methodology has been developed to facilitate this transition, consisting of microfluidic analysis of the device microchannels and a series of cell-related collection experiments building up to in vivo collection. Single-chamber designs were first used to qualitatively demonstrate the feasibility of cell collection ex vivo. This was followed by the development and implementation of devices containing a second, negative-control chamber for quantitative analysis. This work sets the foundation for in vivo cancer cell migration studies utilizing the NANIVID.
| Original language | English (US) |
|---|---|
| Title of host publication | Microfluidics, BioMEMS, and Medical Microsystems XIV |
| Publisher | SPIE |
| Volume | 9705 |
| ISBN (Electronic) | 9781628419399 |
| DOIs | |
| State | Published - 2016 |
| Event | 14th SPIE Photonics West Conference: Microfluidics, BioMEMS, and Medical Microsystems - San Francisco, United States Duration: Feb 13 2016 → Feb 15 2016 |
Other
| Other | 14th SPIE Photonics West Conference: Microfluidics, BioMEMS, and Medical Microsystems |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/13/16 → 2/15/16 |
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Keywords
- cancer
- implantable device
- invasion
- metastasis
- microchannels
- Microfluidics
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Development of microfluidic-based cell collection devices for in vitro and in vivo use. / Butt, Logan; Entenberg, David R.; Hemachandra, L. P Madhubhani; Strohmayer, Matthew; Keely, Patricia; Aguirre-Ghiso, Julio; Condeelis, John S.; Castracane, James.
Microfluidics, BioMEMS, and Medical Microsystems XIV. Vol. 9705 SPIE, 2016. 97051A.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Development of microfluidic-based cell collection devices for in vitro and in vivo use
AU - Butt, Logan
AU - Entenberg, David R.
AU - Hemachandra, L. P Madhubhani
AU - Strohmayer, Matthew
AU - Keely, Patricia
AU - Aguirre-Ghiso, Julio
AU - Condeelis, John S.
AU - Castracane, James
PY - 2016
Y1 - 2016
N2 - The NANIVID - or Nano Intravital Device - is an implantable delivery tool designed to locally affect the tumor microenvironment in vivo. This technology is being redesigned and validated as a cell collection tool for the study of metastatic cancer cells. A methodology has been developed to facilitate this transition, consisting of microfluidic analysis of the device microchannels and a series of cell-related collection experiments building up to in vivo collection. Single-chamber designs were first used to qualitatively demonstrate the feasibility of cell collection ex vivo. This was followed by the development and implementation of devices containing a second, negative-control chamber for quantitative analysis. This work sets the foundation for in vivo cancer cell migration studies utilizing the NANIVID.
AB - The NANIVID - or Nano Intravital Device - is an implantable delivery tool designed to locally affect the tumor microenvironment in vivo. This technology is being redesigned and validated as a cell collection tool for the study of metastatic cancer cells. A methodology has been developed to facilitate this transition, consisting of microfluidic analysis of the device microchannels and a series of cell-related collection experiments building up to in vivo collection. Single-chamber designs were first used to qualitatively demonstrate the feasibility of cell collection ex vivo. This was followed by the development and implementation of devices containing a second, negative-control chamber for quantitative analysis. This work sets the foundation for in vivo cancer cell migration studies utilizing the NANIVID.
KW - cancer
KW - implantable device
KW - invasion
KW - metastasis
KW - microchannels
KW - Microfluidics
UR - http://www.scopus.com/inward/record.url?scp=84973926555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973926555&partnerID=8YFLogxK
U2 - 10.1117/12.2213316
DO - 10.1117/12.2213316
M3 - Conference contribution
VL - 9705
BT - Microfluidics, BioMEMS, and Medical Microsystems XIV
PB - SPIE
ER -