@inproceedings{1251ad5e549d46c98fc2c21a8f5f61cd,
title = "Development of microfluidic-based cell collection devices for in vitro and in vivo use",
abstract = "The NANIVID - or Nano Intravital Device - is an implantable delivery tool designed to locally affect the tumor microenvironment in vivo. This technology is being redesigned and validated as a cell collection tool for the study of metastatic cancer cells. A methodology has been developed to facilitate this transition, consisting of microfluidic analysis of the device microchannels and a series of cell-related collection experiments building up to in vivo collection. Single-chamber designs were first used to qualitatively demonstrate the feasibility of cell collection ex vivo. This was followed by the development and implementation of devices containing a second, negative-control chamber for quantitative analysis. This work sets the foundation for in vivo cancer cell migration studies utilizing the NANIVID.",
keywords = "Microfluidics, cancer, implantable device, invasion, metastasis, microchannels",
author = "Logan Butt and Dave Entenberg and Hemachandra, {L. P.Madhubhani} and Matthew Strohmayer and Patricia Keely and Julio Aguirre-Ghiso and Condeelis, {John S.} and James Castracane",
note = "Funding Information: This work was supported by NIH-NCI grant #U54-CA126511-01 and NSF grant #DBI0922830. Publisher Copyright: {\textcopyright} 2016 SPIE.; 14th SPIE Photonics West Conference: Microfluidics, BioMEMS, and Medical Microsystems ; Conference date: 13-02-2016 Through 15-02-2016",
year = "2016",
doi = "10.1117/12.2213316",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Holger Becker and Gray, {Bonnie L.}",
booktitle = "Microfluidics, BioMEMS, and Medical Microsystems XIV",
}
