Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: A case report from KwaZulu-Natal, South Africa

Richard A. Murphy, Holly France, Henry Sunpath, Michelle L. Gordon, Vincent C. Marconi, Daniel R. Kuritzkes, Kenneth Mcintosh

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Abstract

The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalJournal of Tropical Pediatrics
Volume55
Issue number1
DOIs
Publication statusPublished - Mar 2 2009

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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