Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis

A case report from KwaZulu-Natal, South Africa

Richard A. Murphy, Holly France, Henry Sunpath, Michelle L. Gordon, Vincent C. Marconi, Daniel R. Kuritzkes, Kenneth Mcintosh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalJournal of Tropical Pediatrics
Volume55
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

South Africa
Drug Resistance
Tuberculosis
HIV
Stavudine
Ritonavir
Salvage Therapy
Lamivudine
Drug Interactions
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Cite this

Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis : A case report from KwaZulu-Natal, South Africa. / Murphy, Richard A.; France, Holly; Sunpath, Henry; Gordon, Michelle L.; Marconi, Vincent C.; Kuritzkes, Daniel R.; Mcintosh, Kenneth.

In: Journal of Tropical Pediatrics, Vol. 55, No. 1, 2009, p. 60-62.

Research output: Contribution to journalArticle

Murphy, Richard A. ; France, Holly ; Sunpath, Henry ; Gordon, Michelle L. ; Marconi, Vincent C. ; Kuritzkes, Daniel R. ; Mcintosh, Kenneth. / Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis : A case report from KwaZulu-Natal, South Africa. In: Journal of Tropical Pediatrics. 2009 ; Vol. 55, No. 1. pp. 60-62.
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