TY - JOUR
T1 - Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis
T2 - A case report from KwaZulu-Natal, South Africa
AU - Murphy, Richard A.
AU - France, Holly
AU - Sunpath, Henry
AU - Gordon, Michelle L.
AU - Marconi, Vincent C.
AU - Kuritzkes, Daniel R.
AU - Mcintosh, Kenneth
PY - 2009
Y1 - 2009
N2 - The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.
AB - The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.
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U2 - 10.1093/tropej/fmn074
DO - 10.1093/tropej/fmn074
M3 - Article
C2 - 18786985
AN - SCOPUS:60749085937
SN - 0142-6338
VL - 55
SP - 60
EP - 62
JO - Journal of Tropical Pediatrics
JF - Journal of Tropical Pediatrics
IS - 1
ER -
