Development of an injectable intraocular lens for preservation of accommodation

Nathan Ravi, Roy S. Chuck

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose. To develop a surgical technique for removal of the natural cataractous lens and replace within the capsular bag a synthetic, hydrophilic, nonrigid, intraocular lens that would have the ability to accommodate. Method. Various homo- and copolymer hydrogels were made from appropriate aqueous mixtures of hydroxyethylacrylate, N-vinyl pyrrolidone, diacrylate polyethyleneglycol (PEG), and tetraacrylate PEG. These precursors were reacted in the presence of a catalytic amount of photoinitiator and chain transfer agent. The reaction mixture was illuminated using an argon ion laser at 514 nm to convert the injectable liquid precursor to a hydrogel. Optical, mechanical, density, and equilibrium swelling properties of homo- and colymers were studied. Results. In-situ polymerization and/or gelling of hydroxyethylacrylate was least efficient and most exothermic. Diacrylate and tetraacrylate PEG reacted with minimum heat of reaction and unreacted precursor (measured by low-angle laser light scattering). Optical, mechanical, density and equilibrium swelling were a function the degree of crosslinking. Conclusions. Di- and tetraacrylate terminated PEG gelled in the presence of a biocompatible photoinitiator and argon ion laser seems to be worthy of further investigation as an injectable intraocular lens with accommodative properties.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

Fingerprint

Ocular Accommodation
Gas Lasers
Intraocular Lenses
Injections
Hydrogels
Hydrogel
Polymerization
Lenses
Lasers
Hot Temperature
Light
poly(ethylene glycol)diacrylate

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Development of an injectable intraocular lens for preservation of accommodation. / Ravi, Nathan; Chuck, Roy S.

In: Investigative Ophthalmology and Visual Science, Vol. 37, No. 3, 15.02.1996.

Research output: Contribution to journalArticle

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