@article{fabca012a99e4523a78521ddd2bc9da2,
title = "Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection",
abstract = "Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.",
keywords = "Ebola glycoprotein, Ebola virus, antibody cocktail, antibody engineering, antiviral drug, broadly neutralizing antibodies, ebolavirus, filovirus, human monoclonal antibodies, immunotherapy",
author = "Wec, {Anna Z.} and Bornholdt, {Zachary A.} and Shihua He and Herbert, {Andrew S.} and Eileen Goodwin and Wirchnianski, {Ariel S.} and Gunn, {Bronwyn M.} and Zirui Zhang and Wenjun Zhu and Guodong Liu and Abelson, {Dafna M.} and Moyer, {Crystal L.} and Jangra, {Rohit K.} and James, {Rebekah M.} and Bakken, {Russell R.} and Natasha Bohorova and Ognian Bohorov and Kim, {Do H.} and Pauly, {Michael H.} and Jesus Velasco and Bortz, {Robert H.} and Whaley, {Kevin J.} and Tracey Goldstein and Anthony, {Simon J.} and Galit Alter and Walker, {Laura M.} and Dye, {John M.} and Larry Zeitlin and Xiangguo Qiu and Kartik Chandran",
note = "Funding Information: We thank T. Krause, C. Harold, T. Alkutkar, and I. Gutierrez for technical support and laboratory management. We thank M.J. Aman for provision of mAb CA45. This work is supported by NIH grants AI134824 and AI132256 (to K.C.) and U19AI109762 (to KC., J.M.D., and L.Z.), and by the Public Health Agency of Canada (to X.Q.). L.Z., X.Q., D.M.A., and Z.A.B. were additionally supported by DTRA contract HDTRA1-13-C-0018. K.C. was additionally supported by an Irma T. Hirschl/Monique Weill-Caulier Research Award. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. Funding Information: We thank T. Krause, C. Harold, T. Alkutkar, and I. Gutierrez for technical support and laboratory management. We thank M.J. Aman for provision of mAb CA45. This work is supported by NIH grants AI134824 and AI132256 (to K.C.) and U19AI109762 (to KC., J.M.D., and L.Z.), and by the Public Health Agency of Canada (to X.Q.). L.Z., X.Q., D.M.A., and Z.A.B. were additionally supported by DTRA contract HDTRA1-13-C-0018 . K.C. was additionally supported by an Irma T. Hirschl/Monique Weill-Caulier Research Award. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "9",
doi = "10.1016/j.chom.2018.12.004",
language = "English (US)",
volume = "25",
pages = "39--48.e5",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "1",
}
