@article{fabca012a99e4523a78521ddd2bc9da2,
title = "Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection",
abstract = "Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.",
keywords = "Ebola glycoprotein, Ebola virus, antibody cocktail, antibody engineering, antiviral drug, broadly neutralizing antibodies, ebolavirus, filovirus, human monoclonal antibodies, immunotherapy",
author = "Wec, {Anna Z.} and Bornholdt, {Zachary A.} and Shihua He and Herbert, {Andrew S.} and Eileen Goodwin and Wirchnianski, {Ariel S.} and Gunn, {Bronwyn M.} and Zirui Zhang and Wenjun Zhu and Guodong Liu and Abelson, {Dafna M.} and Moyer, {Crystal L.} and Jangra, {Rohit K.} and James, {Rebekah M.} and Bakken, {Russell R.} and Natasha Bohorova and Ognian Bohorov and Kim, {Do H.} and Pauly, {Michael H.} and Jesus Velasco and Bortz, {Robert H.} and Whaley, {Kevin J.} and Tracey Goldstein and Anthony, {Simon J.} and Galit Alter and Walker, {Laura M.} and Dye, {John M.} and Larry Zeitlin and Xiangguo Qiu and Kartik Chandran",
note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "9",
doi = "10.1016/j.chom.2018.12.004",
language = "English (US)",
volume = "25",
pages = "39--48.e5",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "1",
}
