Development, evaluation, and implementation of a pan-African cancer research network: Men of African descent and carcinoma of the prostate

Caroline Andrews, Brian Fortier, Amy Hayward, Ruth Lederman, Lindsay Petersen, Jo McBride, Desiree C. Petersen, Olabode Ajayi, Paidamoyo Kachambwa, Moleboheng Seutloali, Aubrey Shoko, Mamokhosana Mokhosi, Reinhard Hiller, Marcia Adams, Chrissie Ongaco, Elizabeth Pugh, Jane Romm, Tameka Shelford, Frank Chinegwundoh, Ben AduseiSunny Mante, Nana Yaa Snyper, Ilir Agalliu, David W. Lounsbury, Thomas Rohan, Alex Orfanos, Yuri Quintana, Judith S. Jacobson, Alfred I. Neugut, Edward Gelmann, Joseph Lachance, Cherif Dial, Thierno Amadou Diallo, Mohamed Jalloh, Serigne Magueye Gueye, Papa Moussa Sène Kane, Halimatou Diop, Anna Julienne Ndiaye, Amina Sow Sall, Ndeye Coumba Toure-Kane, Ezenwa Onyemata, Alashle Abimiku, Andrew A. Adjei, Richard Biritwum, Richard Gyasi, Mathew Kyei, James E. Mensah, Julian Okine, Vicky Okyne, Isabella Rockson, Evelyn Tay, Yao Tettey, Edward Yeboah, Wenlong C. Chen, Elvira Singh, Michael B. Cook, Christine N. Duffy, Ann Hsing, Cassandra Claire Soo, Pedro Fernandez, Hayley Irusen, Oseremen Aisuodionoe-Shadrach, Abubakar Mustapha Jamda, Peter Oluwole Olabode, Maxwell Madueke Nwegbu, Olalekan Hafees Ajibola, Olushola Jeremiah Ajamu, Yakubu Garba Ambuwa, Akindele Olupelumi Adebiyi, Michael Asuzu, Olufemi Ogunbiyi, Olufemi Popoola, Olayiwola Shittu, Olukemi Amodu, Emeka Odiaka, Ifeoluwa Makinde, Maureen Joffe, Audrey Pentz, Timothy R. Rebbeck

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

Original languageEnglish (US)
JournalJournal of Global Oncology
Volume2018
Issue number4
DOIs
StatePublished - Mar 1 2018

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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