Development, evaluation, and implementation of a pan-African cancer research network: Men of African descent and carcinoma of the prostate

Caroline Andrews, Brian Fortier, Amy Hayward, Ruth Lederman, Lindsay Petersen, Jo McBride, Desiree C. Petersen, Olabode Ajayi, Paidamoyo Kachambwa, Moleboheng Seutloali, Aubrey Shoko, Mamokhosana Mokhosi, Reinhard Hiller, Marcia Adams, Chrissie Ongaco, Elizabeth Pugh, Jane Romm, Tameka Shelford, Frank Chinegwundoh, Ben AduseiSunny Mante, Nana Yaa Snyper, Ilir Agalliu, David W. Lounsbury, Thomas E. Rohan, Alex Orfanos, Yuri Quintana, Judith S. Jacobson, Alfred I. Neugut, Edward Gelmann, Joseph Lachance, Cherif Dial, Thierno Amadou Diallo, Mohamed Jalloh, Serigne Magueye Gueye, Papa Moussa Sène Kane, Halimatou Diop, Anna Julienne Ndiaye, Amina Sow Sall, Ndeye Coumba Toure-Kane, Ezenwa Onyemata, Alashle Abimiku, Andrew A. Adjei, Richard Biritwum, Richard Gyasi, Mathew Kyei, James E. Mensah, Julian Okine, Vicky Okyne, Isabella Rockson, Evelyn Tay, Yao Tettey, Edward Yeboah, Wenlong C. Chen, Elvira Singh, Michael B. Cook, Christine N. Duffy, Ann Hsing, Cassandra Claire Soo, Pedro Fernandez, Hayley Irusen, Oseremen Aisuodionoe-Shadrach, Abubakar Mustapha Jamda, Peter Oluwole Olabode, Maxwell Madueke Nwegbu, Olalekan Hafees Ajibola, Olushola Jeremiah Ajamu, Yakubu Garba Ambuwa, Akindele Olupelumi Adebiyi, Michael Asuzu, Olufemi Ogunbiyi, Olufemi Popoola, Olayiwola Shittu, Olukemi Amodu, Emeka Odiaka, Ifeoluwa Makinde, Maureen Joffe, Audrey Pentz, Timothy R. Rebbeck

Research output: Contribution to journalArticle

Abstract

Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

Original languageEnglish (US)
JournalJournal of Global Oncology
Volume2018
Issue number4
DOIs
StatePublished - Mar 1 2018

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Africa South of the Sahara
Prostate
Prostatic Neoplasms
Carcinoma
Research
Neoplasms
DNA
Blood Buffy Coat
Genotype
Baltimore
Molecular Epidemiology
Cheek
Genomics
South Africa
Proteomics
Multicenter Studies
Medical Records
Databases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Development, evaluation, and implementation of a pan-African cancer research network : Men of African descent and carcinoma of the prostate. / Andrews, Caroline; Fortier, Brian; Hayward, Amy; Lederman, Ruth; Petersen, Lindsay; McBride, Jo; Petersen, Desiree C.; Ajayi, Olabode; Kachambwa, Paidamoyo; Seutloali, Moleboheng; Shoko, Aubrey; Mokhosi, Mamokhosana; Hiller, Reinhard; Adams, Marcia; Ongaco, Chrissie; Pugh, Elizabeth; Romm, Jane; Shelford, Tameka; Chinegwundoh, Frank; Adusei, Ben; Mante, Sunny; Snyper, Nana Yaa; Agalliu, Ilir; Lounsbury, David W.; Rohan, Thomas E.; Orfanos, Alex; Quintana, Yuri; Jacobson, Judith S.; Neugut, Alfred I.; Gelmann, Edward; Lachance, Joseph; Dial, Cherif; Diallo, Thierno Amadou; Jalloh, Mohamed; Gueye, Serigne Magueye; Kane, Papa Moussa Sène; Diop, Halimatou; Ndiaye, Anna Julienne; Sall, Amina Sow; Toure-Kane, Ndeye Coumba; Onyemata, Ezenwa; Abimiku, Alashle; Adjei, Andrew A.; Biritwum, Richard; Gyasi, Richard; Kyei, Mathew; Mensah, James E.; Okine, Julian; Okyne, Vicky; Rockson, Isabella; Tay, Evelyn; Tettey, Yao; Yeboah, Edward; Chen, Wenlong C.; Singh, Elvira; Cook, Michael B.; Duffy, Christine N.; Hsing, Ann; Soo, Cassandra Claire; Fernandez, Pedro; Irusen, Hayley; Aisuodionoe-Shadrach, Oseremen; Jamda, Abubakar Mustapha; Olabode, Peter Oluwole; Nwegbu, Maxwell Madueke; Ajibola, Olalekan Hafees; Ajamu, Olushola Jeremiah; Ambuwa, Yakubu Garba; Adebiyi, Akindele Olupelumi; Asuzu, Michael; Ogunbiyi, Olufemi; Popoola, Olufemi; Shittu, Olayiwola; Amodu, Olukemi; Odiaka, Emeka; Makinde, Ifeoluwa; Joffe, Maureen; Pentz, Audrey; Rebbeck, Timothy R.

In: Journal of Global Oncology, Vol. 2018, No. 4, 01.03.2018.

Research output: Contribution to journalArticle

Andrews, C, Fortier, B, Hayward, A, Lederman, R, Petersen, L, McBride, J, Petersen, DC, Ajayi, O, Kachambwa, P, Seutloali, M, Shoko, A, Mokhosi, M, Hiller, R, Adams, M, Ongaco, C, Pugh, E, Romm, J, Shelford, T, Chinegwundoh, F, Adusei, B, Mante, S, Snyper, NY, Agalliu, I, Lounsbury, DW, Rohan, TE, Orfanos, A, Quintana, Y, Jacobson, JS, Neugut, AI, Gelmann, E, Lachance, J, Dial, C, Diallo, TA, Jalloh, M, Gueye, SM, Kane, PMS, Diop, H, Ndiaye, AJ, Sall, AS, Toure-Kane, NC, Onyemata, E, Abimiku, A, Adjei, AA, Biritwum, R, Gyasi, R, Kyei, M, Mensah, JE, Okine, J, Okyne, V, Rockson, I, Tay, E, Tettey, Y, Yeboah, E, Chen, WC, Singh, E, Cook, MB, Duffy, CN, Hsing, A, Soo, CC, Fernandez, P, Irusen, H, Aisuodionoe-Shadrach, O, Jamda, AM, Olabode, PO, Nwegbu, MM, Ajibola, OH, Ajamu, OJ, Ambuwa, YG, Adebiyi, AO, Asuzu, M, Ogunbiyi, O, Popoola, O, Shittu, O, Amodu, O, Odiaka, E, Makinde, I, Joffe, M, Pentz, A & Rebbeck, TR 2018, 'Development, evaluation, and implementation of a pan-African cancer research network: Men of African descent and carcinoma of the prostate', Journal of Global Oncology, vol. 2018, no. 4. https://doi.org/10.1200/JGO.18.00063
Andrews, Caroline ; Fortier, Brian ; Hayward, Amy ; Lederman, Ruth ; Petersen, Lindsay ; McBride, Jo ; Petersen, Desiree C. ; Ajayi, Olabode ; Kachambwa, Paidamoyo ; Seutloali, Moleboheng ; Shoko, Aubrey ; Mokhosi, Mamokhosana ; Hiller, Reinhard ; Adams, Marcia ; Ongaco, Chrissie ; Pugh, Elizabeth ; Romm, Jane ; Shelford, Tameka ; Chinegwundoh, Frank ; Adusei, Ben ; Mante, Sunny ; Snyper, Nana Yaa ; Agalliu, Ilir ; Lounsbury, David W. ; Rohan, Thomas E. ; Orfanos, Alex ; Quintana, Yuri ; Jacobson, Judith S. ; Neugut, Alfred I. ; Gelmann, Edward ; Lachance, Joseph ; Dial, Cherif ; Diallo, Thierno Amadou ; Jalloh, Mohamed ; Gueye, Serigne Magueye ; Kane, Papa Moussa Sène ; Diop, Halimatou ; Ndiaye, Anna Julienne ; Sall, Amina Sow ; Toure-Kane, Ndeye Coumba ; Onyemata, Ezenwa ; Abimiku, Alashle ; Adjei, Andrew A. ; Biritwum, Richard ; Gyasi, Richard ; Kyei, Mathew ; Mensah, James E. ; Okine, Julian ; Okyne, Vicky ; Rockson, Isabella ; Tay, Evelyn ; Tettey, Yao ; Yeboah, Edward ; Chen, Wenlong C. ; Singh, Elvira ; Cook, Michael B. ; Duffy, Christine N. ; Hsing, Ann ; Soo, Cassandra Claire ; Fernandez, Pedro ; Irusen, Hayley ; Aisuodionoe-Shadrach, Oseremen ; Jamda, Abubakar Mustapha ; Olabode, Peter Oluwole ; Nwegbu, Maxwell Madueke ; Ajibola, Olalekan Hafees ; Ajamu, Olushola Jeremiah ; Ambuwa, Yakubu Garba ; Adebiyi, Akindele Olupelumi ; Asuzu, Michael ; Ogunbiyi, Olufemi ; Popoola, Olufemi ; Shittu, Olayiwola ; Amodu, Olukemi ; Odiaka, Emeka ; Makinde, Ifeoluwa ; Joffe, Maureen ; Pentz, Audrey ; Rebbeck, Timothy R. / Development, evaluation, and implementation of a pan-African cancer research network : Men of African descent and carcinoma of the prostate. In: Journal of Global Oncology. 2018 ; Vol. 2018, No. 4.
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title = "Development, evaluation, and implementation of a pan-African cancer research network: Men of African descent and carcinoma of the prostate",
abstract = "Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95{\%} to 98{\%} concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95{\%} of tested DNA samples (100{\%} from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.",
author = "Caroline Andrews and Brian Fortier and Amy Hayward and Ruth Lederman and Lindsay Petersen and Jo McBride and Petersen, {Desiree C.} and Olabode Ajayi and Paidamoyo Kachambwa and Moleboheng Seutloali and Aubrey Shoko and Mamokhosana Mokhosi and Reinhard Hiller and Marcia Adams and Chrissie Ongaco and Elizabeth Pugh and Jane Romm and Tameka Shelford and Frank Chinegwundoh and Ben Adusei and Sunny Mante and Snyper, {Nana Yaa} and Ilir Agalliu and Lounsbury, {David W.} and Rohan, {Thomas E.} and Alex Orfanos and Yuri Quintana and Jacobson, {Judith S.} and Neugut, {Alfred I.} and Edward Gelmann and Joseph Lachance and Cherif Dial and Diallo, {Thierno Amadou} and Mohamed Jalloh and Gueye, {Serigne Magueye} and Kane, {Papa Moussa S{\`e}ne} and Halimatou Diop and Ndiaye, {Anna Julienne} and Sall, {Amina Sow} and Toure-Kane, {Ndeye Coumba} and Ezenwa Onyemata and Alashle Abimiku and Adjei, {Andrew A.} and Richard Biritwum and Richard Gyasi and Mathew Kyei and Mensah, {James E.} and Julian Okine and Vicky Okyne and Isabella Rockson and Evelyn Tay and Yao Tettey and Edward Yeboah and Chen, {Wenlong C.} and Elvira Singh and Cook, {Michael B.} and Duffy, {Christine N.} and Ann Hsing and Soo, {Cassandra Claire} and Pedro Fernandez and Hayley Irusen and Oseremen Aisuodionoe-Shadrach and Jamda, {Abubakar Mustapha} and Olabode, {Peter Oluwole} and Nwegbu, {Maxwell Madueke} and Ajibola, {Olalekan Hafees} and Ajamu, {Olushola Jeremiah} and Ambuwa, {Yakubu Garba} and Adebiyi, {Akindele Olupelumi} and Michael Asuzu and Olufemi Ogunbiyi and Olufemi Popoola and Olayiwola Shittu and Olukemi Amodu and Emeka Odiaka and Ifeoluwa Makinde and Maureen Joffe and Audrey Pentz and Rebbeck, {Timothy R.}",
year = "2018",
month = "3",
day = "1",
doi = "10.1200/JGO.18.00063",
language = "English (US)",
volume = "2018",
journal = "Journal of global oncology",
issn = "2378-9506",
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TY - JOUR

T1 - Development, evaluation, and implementation of a pan-African cancer research network

T2 - Men of African descent and carcinoma of the prostate

AU - Andrews, Caroline

AU - Fortier, Brian

AU - Hayward, Amy

AU - Lederman, Ruth

AU - Petersen, Lindsay

AU - McBride, Jo

AU - Petersen, Desiree C.

AU - Ajayi, Olabode

AU - Kachambwa, Paidamoyo

AU - Seutloali, Moleboheng

AU - Shoko, Aubrey

AU - Mokhosi, Mamokhosana

AU - Hiller, Reinhard

AU - Adams, Marcia

AU - Ongaco, Chrissie

AU - Pugh, Elizabeth

AU - Romm, Jane

AU - Shelford, Tameka

AU - Chinegwundoh, Frank

AU - Adusei, Ben

AU - Mante, Sunny

AU - Snyper, Nana Yaa

AU - Agalliu, Ilir

AU - Lounsbury, David W.

AU - Rohan, Thomas E.

AU - Orfanos, Alex

AU - Quintana, Yuri

AU - Jacobson, Judith S.

AU - Neugut, Alfred I.

AU - Gelmann, Edward

AU - Lachance, Joseph

AU - Dial, Cherif

AU - Diallo, Thierno Amadou

AU - Jalloh, Mohamed

AU - Gueye, Serigne Magueye

AU - Kane, Papa Moussa Sène

AU - Diop, Halimatou

AU - Ndiaye, Anna Julienne

AU - Sall, Amina Sow

AU - Toure-Kane, Ndeye Coumba

AU - Onyemata, Ezenwa

AU - Abimiku, Alashle

AU - Adjei, Andrew A.

AU - Biritwum, Richard

AU - Gyasi, Richard

AU - Kyei, Mathew

AU - Mensah, James E.

AU - Okine, Julian

AU - Okyne, Vicky

AU - Rockson, Isabella

AU - Tay, Evelyn

AU - Tettey, Yao

AU - Yeboah, Edward

AU - Chen, Wenlong C.

AU - Singh, Elvira

AU - Cook, Michael B.

AU - Duffy, Christine N.

AU - Hsing, Ann

AU - Soo, Cassandra Claire

AU - Fernandez, Pedro

AU - Irusen, Hayley

AU - Aisuodionoe-Shadrach, Oseremen

AU - Jamda, Abubakar Mustapha

AU - Olabode, Peter Oluwole

AU - Nwegbu, Maxwell Madueke

AU - Ajibola, Olalekan Hafees

AU - Ajamu, Olushola Jeremiah

AU - Ambuwa, Yakubu Garba

AU - Adebiyi, Akindele Olupelumi

AU - Asuzu, Michael

AU - Ogunbiyi, Olufemi

AU - Popoola, Olufemi

AU - Shittu, Olayiwola

AU - Amodu, Olukemi

AU - Odiaka, Emeka

AU - Makinde, Ifeoluwa

AU - Joffe, Maureen

AU - Pentz, Audrey

AU - Rebbeck, Timothy R.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

AB - Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.

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U2 - 10.1200/JGO.18.00063

DO - 10.1200/JGO.18.00063

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C2 - 30260755

AN - SCOPUS:85060561295

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JO - Journal of global oncology

JF - Journal of global oncology

SN - 2378-9506

IS - 4

ER -