Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma

Seth Rakoff-Nahoum, Peter J. Kuebler, Jonas J. Heymann, Megan E. Sheehy, Gabriel M. Ortiz, Graham S. Ogg, Jason D. Barbour, Jack Lenz, Alan D. Steinfeld, Douglas F. Nixon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Human endogenous retro virus K (HERV-K) is distinctive among the retro viruses that comprise about 8% of the human genome in that multiple HERV-K proviruses encode full-length viral proteins, and many HERV-K proviruses formed during recent human evolution. HERV-K gag proteins are found in the cytoplasm of primary tumor cells of patients with seminoma. We identified HERV-K-specific T cells in patients with a past history of seminoma using the interferon-gamma ELISPOT assay and an MHC-HERV-K peptide-specific tetramer. A minority of apparently healthy subjects without evident germ cell tumors also made HERV-K-specific T cell responses. In summary, we detected T cell reactivity to HERV-K peptides in both past seminoma patients and a minority of apparently healthy controls.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume22
Issue number1
DOIs
StatePublished - Jan 2006

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Endogenous Retroviruses
Seminoma
T-Lymphocytes
Proviruses
Viruses
gag Gene Products
Enzyme-Linked Immunospot Assay
Peptides
Germ Cell and Embryonal Neoplasms
Viral Proteins
Human Genome
Interferon-gamma
Healthy Volunteers
Cytoplasm

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Rakoff-Nahoum, S., Kuebler, P. J., Heymann, J. J., Sheehy, M. E., Ortiz, G. M., Ogg, G. S., ... Nixon, D. F. (2006). Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. AIDS Research and Human Retroviruses, 22(1), 52-56. https://doi.org/10.1089/aid.2006.22.52

Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. / Rakoff-Nahoum, Seth; Kuebler, Peter J.; Heymann, Jonas J.; Sheehy, Megan E.; Ortiz, Gabriel M.; Ogg, Graham S.; Barbour, Jason D.; Lenz, Jack; Steinfeld, Alan D.; Nixon, Douglas F.

In: AIDS Research and Human Retroviruses, Vol. 22, No. 1, 01.2006, p. 52-56.

Research output: Contribution to journalArticle

Rakoff-Nahoum, S, Kuebler, PJ, Heymann, JJ, Sheehy, ME, Ortiz, GM, Ogg, GS, Barbour, JD, Lenz, J, Steinfeld, AD & Nixon, DF 2006, 'Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma', AIDS Research and Human Retroviruses, vol. 22, no. 1, pp. 52-56. https://doi.org/10.1089/aid.2006.22.52
Rakoff-Nahoum, Seth ; Kuebler, Peter J. ; Heymann, Jonas J. ; Sheehy, Megan E. ; Ortiz, Gabriel M. ; Ogg, Graham S. ; Barbour, Jason D. ; Lenz, Jack ; Steinfeld, Alan D. ; Nixon, Douglas F. / Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. In: AIDS Research and Human Retroviruses. 2006 ; Vol. 22, No. 1. pp. 52-56.
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