Detection of Coronary Artery Stenosis Using 40-Channel Computed Tomography With Multisegment Reconstruction

Matthew W. Watkins, Barbara Hesse, Curtis E. Green, Neil L. Greenberg, Michael Manning, Eram Chaudhry, Harold L. Dauerman, Mario J. Garcia

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Coronary angiographic studies performed with 16-channel multidetector computer tomographic scanners have demonstrated accurate detection of coronary vessel stenosis but are limited by a significant number of nonevaluable segments. To date, only single-center experience with multidetector computer tomography has been reported. We performed a prospective, blinded study at 2 institutions to determine the feasibility and diagnostic accuracy of coronary angiography using 40-channel multidetector computer tomography with multisegment reconstruction for the detection of obstructive coronary artery disease (CAD). Multidetector computer tomographic studies were performed in 85 patients who were referred for invasive coronary angiography with clinically suspected CAD. Datasets were analyzed by blinded, independent review. Of 1,145 segments that were suitable for analysis as determined by angiography, 1,045 (91.3%) were evaluable on multidetector computer tomography. Segment-based sensitivity, specificity, and positive and negative predictive values for detecting ≥50% luminal stenoses were 86%, 97%, 75%, and 97%, respectively. The area under the receiver-operating characteristic curves for the detection of ≥50% angiographic stenosis by multidetector computer tomography was 0.94. In a patient-based analysis, the sensitivity, specificity, and positive and negative predictive values for detecting subjects with ≥1 segment with ≥50% stenosis were 98%, 93%, 94% and 93%, respectively. In conclusion, coronary angiography using 40-channel multidetector computer tomography with multisegment reconstruction accurately detects coronary segments and patients with obstructive CAD, with a small number of nonevaluable cases.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalAmerican Journal of Cardiology
Volume99
Issue number2
DOIs
StatePublished - Jan 15 2007
Externally publishedYes

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Coronary Stenosis
Tomography
Coronary Angiography
Coronary Artery Disease
Pathologic Constriction
Sensitivity and Specificity
ROC Curve
Coronary Vessels
Angiography
Prospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Detection of Coronary Artery Stenosis Using 40-Channel Computed Tomography With Multisegment Reconstruction. / Watkins, Matthew W.; Hesse, Barbara; Green, Curtis E.; Greenberg, Neil L.; Manning, Michael; Chaudhry, Eram; Dauerman, Harold L.; Garcia, Mario J.

In: American Journal of Cardiology, Vol. 99, No. 2, 15.01.2007, p. 175-181.

Research output: Contribution to journalArticle

Watkins, Matthew W. ; Hesse, Barbara ; Green, Curtis E. ; Greenberg, Neil L. ; Manning, Michael ; Chaudhry, Eram ; Dauerman, Harold L. ; Garcia, Mario J. / Detection of Coronary Artery Stenosis Using 40-Channel Computed Tomography With Multisegment Reconstruction. In: American Journal of Cardiology. 2007 ; Vol. 99, No. 2. pp. 175-181.
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