Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald, Peter Gierschik, Marshall Nirenberg, Allen M. Spiegel

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

Original languageEnglish (US)
Pages (from-to)856-859
Number of pages4
JournalScience
Volume231
Issue number4740
StatePublished - 1986
Externally publishedYes

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Transducin
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Light Signal Transduction
Guanosine Monophosphate
Rhodopsin
Guanine Nucleotides
Phosphoric Diester Hydrolases
Retina
Chickens
Carrier Proteins
Light

ASJC Scopus subject areas

  • General

Cite this

Grunwald, G. B., Gierschik, P., Nirenberg, M., & Spiegel, A. M. (1986). Detection of α-transducin in retinal rods but not cones. Science, 231(4740), 856-859.

Detection of α-transducin in retinal rods but not cones. / Grunwald, Gerald B.; Gierschik, Peter; Nirenberg, Marshall; Spiegel, Allen M.

In: Science, Vol. 231, No. 4740, 1986, p. 856-859.

Research output: Contribution to journalArticle

Grunwald, GB, Gierschik, P, Nirenberg, M & Spiegel, AM 1986, 'Detection of α-transducin in retinal rods but not cones', Science, vol. 231, no. 4740, pp. 856-859.
Grunwald GB, Gierschik P, Nirenberg M, Spiegel AM. Detection of α-transducin in retinal rods but not cones. Science. 1986;231(4740):856-859.
Grunwald, Gerald B. ; Gierschik, Peter ; Nirenberg, Marshall ; Spiegel, Allen M. / Detection of α-transducin in retinal rods but not cones. In: Science. 1986 ; Vol. 231, No. 4740. pp. 856-859.
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