Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald; Peter Gierschik; Marshall Nirenberg; Allen Spiegel

doi:10.1126/science.3080807

Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald, Peter Gierschik, Marshall Nirenberg, Allen Spiegel

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

Original language	English (US)
Pages (from-to)	856-859
Number of pages	4
Journal	Science
Volume	231
Issue number	4740
DOIs	https://doi.org/10.1126/science.3080807
State	Published - Jan 1 1986
Externally published	Yes

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title = "Detection of α-transducin in retinal rods but not cones",

abstract = "The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.",

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AU - Grunwald, Gerald B.

AU - Gierschik, Peter

AU - Nirenberg, Marshall

AU - Spiegel, Allen

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

AB - The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

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Detection of α-transducin in retinal rods but not cones

Abstract

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