Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald, Peter Gierschik, Marshall Nirenberg, Allen Spiegel

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

Original languageEnglish (US)
Pages (from-to)856-859
Number of pages4
JournalScience
Volume231
Issue number4740
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • General

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