Detection of α-transducin in retinal rods but not cones

Gerald B. Grunwald, Peter Gierschik, Marshall Nirenberg, Allen Spiegel

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Abstract

The distribution in chicken retina of the a subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiscrum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

Original languageEnglish (US)
Pages (from-to)856-859
Number of pages4
JournalScience
Volume231
Issue number4740
DOIs
Publication statusPublished - Jan 1 1986
Externally publishedYes

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Cite this

Grunwald, G. B., Gierschik, P., Nirenberg, M., & Spiegel, A. (1986). Detection of α-transducin in retinal rods but not cones. Science, 231(4740), 856-859. https://doi.org/10.1126/science.3080807