Detecting dementia with the Hopkins Verbal Learning Test and the Mini-Mental State Examination

Gail Kuslansky, Mindy Joy Katz, Joe Verghese, Charles B. Hall, Pablo Lapuerta, Gia LaRuffa, Richard B. Lipton

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The Hopkins Verbal Learning Test (HVLT) and the Mini-Mental State Examination (MMSE) were administered to 323 non-demented elderly and 70 individuals who meet DSM-IV criteria for dementia in order to compare the validity of these two measures for detecting mild dementia and for the two most common dementia subtypes, Alzheimer's disease (AD) and vascular dementia (VaD). The study was conducted in an elderly, ethnically diverse community-dwelling population. Sensitivity, specificity, positive and negative predictive values were calculated over a range of clinically relevant cut scores for each test. We analyzed the influence of age, education, reading ability and sex on test performance using logistic regression models. When sensitivity is held constant at 0.69, the specificity for the HVLT total recall was 0.89 and the MMSE 0.82 for all dementias (P=.10). Age, sex and education did not significantly influence test performance for either test in this sample. Results were similar for AD and VaD. However, while adding a measure of reading ability to the regression models did not affect the overall dementia model, it resulted in improved specificities when combined with the MMSE for AD and combined with the HVLT for VaD. Additional tests such as reading ability can improve discrimination of dementia subtypes. The modest sensitivity of either the HVLT or the MMSE alone suggests that further neuropsychological evaluation is required to confirm dementia diagnosis.

Original languageEnglish (US)
Pages (from-to)89-104
Number of pages16
JournalArchives of Clinical Neuropsychology
Volume19
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Verbal Learning
Intelligence Tests
Dementia
Alzheimer Disease
Vascular Dementia
Aptitude
Reading
Logistic Models
Independent Living
Sex Education
Diagnostic and Statistical Manual of Mental Disorders
Education
Sensitivity and Specificity
Population

Keywords

  • Alzheimer's disease (AD)
  • Area under the curve (AUC)
  • Hopkins Verbal Learning Test (HVLT)
  • Mini-Mental State Examination (MMSE)
  • Receiver operating characteristic (ROC)
  • Vascular dementia (VaD)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Detecting dementia with the Hopkins Verbal Learning Test and the Mini-Mental State Examination. / Kuslansky, Gail; Katz, Mindy Joy; Verghese, Joe; Hall, Charles B.; Lapuerta, Pablo; LaRuffa, Gia; Lipton, Richard B.

In: Archives of Clinical Neuropsychology, Vol. 19, No. 1, 01.2004, p. 89-104.

Research output: Contribution to journalArticle

@article{77ffcc87a8104f5d83db13573dcaafd1,
title = "Detecting dementia with the Hopkins Verbal Learning Test and the Mini-Mental State Examination",
abstract = "The Hopkins Verbal Learning Test (HVLT) and the Mini-Mental State Examination (MMSE) were administered to 323 non-demented elderly and 70 individuals who meet DSM-IV criteria for dementia in order to compare the validity of these two measures for detecting mild dementia and for the two most common dementia subtypes, Alzheimer's disease (AD) and vascular dementia (VaD). The study was conducted in an elderly, ethnically diverse community-dwelling population. Sensitivity, specificity, positive and negative predictive values were calculated over a range of clinically relevant cut scores for each test. We analyzed the influence of age, education, reading ability and sex on test performance using logistic regression models. When sensitivity is held constant at 0.69, the specificity for the HVLT total recall was 0.89 and the MMSE 0.82 for all dementias (P=.10). Age, sex and education did not significantly influence test performance for either test in this sample. Results were similar for AD and VaD. However, while adding a measure of reading ability to the regression models did not affect the overall dementia model, it resulted in improved specificities when combined with the MMSE for AD and combined with the HVLT for VaD. Additional tests such as reading ability can improve discrimination of dementia subtypes. The modest sensitivity of either the HVLT or the MMSE alone suggests that further neuropsychological evaluation is required to confirm dementia diagnosis.",
keywords = "Alzheimer's disease (AD), Area under the curve (AUC), Hopkins Verbal Learning Test (HVLT), Mini-Mental State Examination (MMSE), Receiver operating characteristic (ROC), Vascular dementia (VaD)",
author = "Gail Kuslansky and Katz, {Mindy Joy} and Joe Verghese and Hall, {Charles B.} and Pablo Lapuerta and Gia LaRuffa and Lipton, {Richard B.}",
year = "2004",
month = "1",
doi = "10.1016/S0887-6177(02)00217-2",
language = "English (US)",
volume = "19",
pages = "89--104",
journal = "Archives of Clinical Neuropsychology",
issn = "1873-5843",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Detecting dementia with the Hopkins Verbal Learning Test and the Mini-Mental State Examination

AU - Kuslansky, Gail

AU - Katz, Mindy Joy

AU - Verghese, Joe

AU - Hall, Charles B.

AU - Lapuerta, Pablo

AU - LaRuffa, Gia

AU - Lipton, Richard B.

PY - 2004/1

Y1 - 2004/1

N2 - The Hopkins Verbal Learning Test (HVLT) and the Mini-Mental State Examination (MMSE) were administered to 323 non-demented elderly and 70 individuals who meet DSM-IV criteria for dementia in order to compare the validity of these two measures for detecting mild dementia and for the two most common dementia subtypes, Alzheimer's disease (AD) and vascular dementia (VaD). The study was conducted in an elderly, ethnically diverse community-dwelling population. Sensitivity, specificity, positive and negative predictive values were calculated over a range of clinically relevant cut scores for each test. We analyzed the influence of age, education, reading ability and sex on test performance using logistic regression models. When sensitivity is held constant at 0.69, the specificity for the HVLT total recall was 0.89 and the MMSE 0.82 for all dementias (P=.10). Age, sex and education did not significantly influence test performance for either test in this sample. Results were similar for AD and VaD. However, while adding a measure of reading ability to the regression models did not affect the overall dementia model, it resulted in improved specificities when combined with the MMSE for AD and combined with the HVLT for VaD. Additional tests such as reading ability can improve discrimination of dementia subtypes. The modest sensitivity of either the HVLT or the MMSE alone suggests that further neuropsychological evaluation is required to confirm dementia diagnosis.

AB - The Hopkins Verbal Learning Test (HVLT) and the Mini-Mental State Examination (MMSE) were administered to 323 non-demented elderly and 70 individuals who meet DSM-IV criteria for dementia in order to compare the validity of these two measures for detecting mild dementia and for the two most common dementia subtypes, Alzheimer's disease (AD) and vascular dementia (VaD). The study was conducted in an elderly, ethnically diverse community-dwelling population. Sensitivity, specificity, positive and negative predictive values were calculated over a range of clinically relevant cut scores for each test. We analyzed the influence of age, education, reading ability and sex on test performance using logistic regression models. When sensitivity is held constant at 0.69, the specificity for the HVLT total recall was 0.89 and the MMSE 0.82 for all dementias (P=.10). Age, sex and education did not significantly influence test performance for either test in this sample. Results were similar for AD and VaD. However, while adding a measure of reading ability to the regression models did not affect the overall dementia model, it resulted in improved specificities when combined with the MMSE for AD and combined with the HVLT for VaD. Additional tests such as reading ability can improve discrimination of dementia subtypes. The modest sensitivity of either the HVLT or the MMSE alone suggests that further neuropsychological evaluation is required to confirm dementia diagnosis.

KW - Alzheimer's disease (AD)

KW - Area under the curve (AUC)

KW - Hopkins Verbal Learning Test (HVLT)

KW - Mini-Mental State Examination (MMSE)

KW - Receiver operating characteristic (ROC)

KW - Vascular dementia (VaD)

UR - http://www.scopus.com/inward/record.url?scp=0345550235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345550235&partnerID=8YFLogxK

U2 - 10.1016/S0887-6177(02)00217-2

DO - 10.1016/S0887-6177(02)00217-2

M3 - Article

VL - 19

SP - 89

EP - 104

JO - Archives of Clinical Neuropsychology

JF - Archives of Clinical Neuropsychology

SN - 1873-5843

IS - 1

ER -