Desperately seeking sugar

Glial cells as hypoglycemia sensors

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A life-saving response to hypoglycemia requires rapid sensing of decreases in glycemia and consequent brisk glucagon secretion. Preceding studies have shown that mice lacking glucose transporter type 2 (GLUT2) lose this response. In this issue of the JCI, Marty et al. report that glucose sensing and consequent pancreatic glucagon secretion are restored by re-expression of GLUT2 in glial but not neuronal cells (see the related article beginning on page 3545). A new, glucose-sensing role is ascribed to GLUT2-expressing glial cells.

Original languageEnglish (US)
Pages (from-to)3403-3405
Number of pages3
JournalJournal of Clinical Investigation
Volume115
Issue number12
DOIs
StatePublished - Dec 2005

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Glucose Transporter Type 2
Hypoglycemia
Neuroglia
Glucagon
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Desperately seeking sugar : Glial cells as hypoglycemia sensors. / Klip, Amira; Hawkins, Meredith A.

In: Journal of Clinical Investigation, Vol. 115, No. 12, 12.2005, p. 3403-3405.

Research output: Contribution to journalArticle

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