Demonstration of Nitrogen Coordination in Metal-Bleomycin Complexes by Electron Spin-Echo Envelope Spectroscopy

R. M. Burger; A. D. Adler; S. B. Horwitz; W. B. Mims; J. Peisach

doi:10.1021/bi00509a045

Demonstration of Nitrogen Coordination in Metal-Bleomycin Complexes by Electron Spin-Echo Envelope Spectroscopy

R. M. Burger, A. D. Adler, S. B. Horwitz, W. B. Mims, J. Peisach

Molecular Pharmacology

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30 Scopus citations

Abstract

We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin-echo envelope spectroscopy. For all three complexes, nitrogen coordination of the metal ion is demonstrated For the Cu(II)- and Co(II)-drug complexes, we have been able to identify imidazole as a metal ligand.

Original language	English (US)
Pages (from-to)	1701-1704
Number of pages	4
Journal	Biochemistry
Volume	20
Issue number	6
DOIs	https://doi.org/10.1021/bi00509a045
State	Published - Mar 1981

ASJC Scopus subject areas

Biochemistry

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title = "Demonstration of Nitrogen Coordination in Metal-Bleomycin Complexes by Electron Spin-Echo Envelope Spectroscopy",

abstract = "We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin-echo envelope spectroscopy. For all three complexes, nitrogen coordination of the metal ion is demonstrated For the Cu(II)- and Co(II)-drug complexes, we have been able to identify imidazole as a metal ligand.",

author = "Burger, {R. M.} and Adler, {A. D.} and Horwitz, {S. B.} and Mims, {W. B.} and J. Peisach",

year = "1981",

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AU - Burger, R. M.

AU - Adler, A. D.

AU - Horwitz, S. B.

AU - Mims, W. B.

AU - Peisach, J.

PY - 1981/3

Y1 - 1981/3

N2 - We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin-echo envelope spectroscopy. For all three complexes, nitrogen coordination of the metal ion is demonstrated For the Cu(II)- and Co(II)-drug complexes, we have been able to identify imidazole as a metal ligand.

AB - We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin-echo envelope spectroscopy. For all three complexes, nitrogen coordination of the metal ion is demonstrated For the Cu(II)- and Co(II)-drug complexes, we have been able to identify imidazole as a metal ligand.

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Demonstration of Nitrogen Coordination in Metal-Bleomycin Complexes by Electron Spin-Echo Envelope Spectroscopy

Abstract

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