Demonstration of mismatch negativity in the monkey

Daniel C. Javitt, Charles E. Schroeder, Mitchell Steinschneider, Joseph C. Arezzo, Herbert G. Vaughan,

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalElectroencephalography and clinical neurophysiology
Volume83
Issue number1
DOIs
StatePublished - Jul 1992

Keywords

  • "Oddball"
  • Auditory
  • Cognitive
  • Event-related potentials
  • P300

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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