Demonstration of mismatch negativity in the monkey

Daniel C. Javitt; Charles E. Schroeder; Mitchell Steinschneider; Joseph C. Arezzo; Herbert G. Vaughan,

doi:10.1016/0013-4694(92)90137-7

Demonstration of mismatch negativity in the monkey

Daniel C. Javitt, Charles E. Schroeder, Mitchell Steinschneider, Joseph C. Arezzo, Herbert G. Vaughan,

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

Original language	English (US)
Pages (from-to)	87-90
Number of pages	4
Journal	Electroencephalography and clinical neurophysiology
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/0013-4694(92)90137-7
State	Published - Jul 1992

Keywords

"Oddball"
Auditory
Cognitive
Event-related potentials
P300

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1016/0013-4694(92)90137-7

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@article{7206656fec5c4dd291dfa8d9bbeccdae,

title = "Demonstration of mismatch negativity in the monkey",

abstract = "In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed {"}mismatch negativity{"} (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. {"}Oddball{"} loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.",

keywords = "{"}Oddball{"}, Auditory, Cognitive, Event-related potentials, P300",

author = "Javitt, {Daniel C.} and Schroeder, {Charles E.} and Mitchell Steinschneider and Arezzo, {Joseph C.} and Vaughan,, {Herbert G.}",

note = "Funding Information: Support for this work was provided by P.H.S. Grants Kll MH00631 (DCJ), R03 MH46962 (DCJ) and MH06723 (JCA) and a NARSAD Young Investigator Award (DCJ).",

year = "1992",

month = jul,

doi = "10.1016/0013-4694(92)90137-7",

language = "English (US)",

volume = "83",

pages = "87--90",

journal = "Electroencephalography and Clinical Neurophysiology",

issn = "0013-4694",

publisher = "Elsevier BV",

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AU - Javitt, Daniel C.

AU - Schroeder, Charles E.

AU - Steinschneider, Mitchell

AU - Arezzo, Joseph C.

AU - Vaughan,, Herbert G.

N1 - Funding Information: Support for this work was provided by P.H.S. Grants Kll MH00631 (DCJ), R03 MH46962 (DCJ) and MH06723 (JCA) and a NARSAD Young Investigator Award (DCJ).

PY - 1992/7

Y1 - 1992/7

N2 - In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

AB - In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

KW - "Oddball"

KW - Auditory

KW - Cognitive

KW - Event-related potentials

KW - P300

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JO - Electroencephalography and Clinical Neurophysiology

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Demonstration of mismatch negativity in the monkey

Abstract

Keywords

ASJC Scopus subject areas

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