Demonstration of mismatch negativity in the monkey

Daniel C. Javitt, Charles E. Schroeder, Mitchell Steinschneider, Joseph C. Arezzo, Herbert G. Vaughan,

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalElectroencephalography and Clinical Neurophysiology
Volume83
Issue number1
DOIs
StatePublished - 1992

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Keywords

  • "Oddball"
  • Auditory
  • Cognitive
  • Event-related potentials
  • P300

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Demonstration of mismatch negativity in the monkey. / Javitt, Daniel C.; Schroeder, Charles E.; Steinschneider, Mitchell; Arezzo, Joseph C.; Vaughan, Herbert G.

In: Electroencephalography and Clinical Neurophysiology, Vol. 83, No. 1, 1992, p. 87-90.

Research output: Contribution to journalArticle

Javitt, Daniel C. ; Schroeder, Charles E. ; Steinschneider, Mitchell ; Arezzo, Joseph C. ; Vaughan, Herbert G. / Demonstration of mismatch negativity in the monkey. In: Electroencephalography and Clinical Neurophysiology. 1992 ; Vol. 83, No. 1. pp. 87-90.
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