Demonstration of β amyloid protein-containing neurofibrillary tangles in parkinsonism-dementia complex on Guam

H. Ito, A. Hirano, S. H. Yen, S. Kato

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This report concerns the immunohistochemical demonstration of β amyloid protein-containing neurofibrillary tangles (β-NFTs) from patients with parkinsonism-dementia complex on Guam (PDC). Formalin-fixed paraffin-embedded tissue sections from the temporal lobe of nine PDC cases and the spinal cord of three were examined. An affinity-purified antibody to the N-terminal peptide sequence of β amyloid protein was used. β-NFTs were demonstrated in the temporal lobes of the three oldest individuals. Some senile plaques, probably a manifestation of ageing, were also seen. The β-NFTs were most frequent in the entorhinal cortex. Senile plaques were invariably present in the vicinity of the β-NFTs. Conversely, in the regions without senile plaques, even though numerous neurofibrillary tangles were identifiable with the modified Bielschowsky method, no β-NFTs were seen. The density of β-NFTs appeared to be proportional to that of senile plaques, none was seen in cases lacking senile plaques. No β-NFTs were detected in the spinal cords. Our data suggest that β-NFTs result from secondary amyloid deposition on certain neurofibrillary tangles.

Original languageEnglish (US)
Pages (from-to)365-373
Number of pages9
JournalNeuropathology and Applied Neurobiology
Volume17
Issue number5
StatePublished - 1991

Fingerprint

Guam
Amyloidogenic Proteins
Neurofibrillary Tangles
Amyloid Plaques
Parkinsonian Disorders
Dementia
Temporal Lobe
Spinal Cord
Entorhinal Cortex
Antibody Affinity
Amyloid
Paraffin
Formaldehyde
Peptides

Keywords

  • β protein
  • Amyloid
  • Entorhinal cortex
  • Hippocampus
  • Neurofibrillary tangles
  • Parkinsonism-dementia complex on Guam
  • Senile plaques
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Demonstration of β amyloid protein-containing neurofibrillary tangles in parkinsonism-dementia complex on Guam. / Ito, H.; Hirano, A.; Yen, S. H.; Kato, S.

In: Neuropathology and Applied Neurobiology, Vol. 17, No. 5, 1991, p. 365-373.

Research output: Contribution to journalArticle

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