Definition of a small core transcriptional circuit regulated by AML1-ETO

Kristy R. Stengel, Jacob D. Ellis, Clare L. Spielman, Monica L. Bomber, Scott W. Hiebert

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Stengel et al. combine PROTAC-mediated degradation of the oncogenic transcription factor AML1-ETO with nascent transcript analysis to identify direct gene targets. AML1-ETO-mediated repression of this small gene network impairs myeloid differentiation. This provides a model for the identification of transcriptional circuits directly controlled by transcription factors.

Original languageEnglish (US)
Pages (from-to)530-545.e5
JournalMolecular Cell
Volume81
Issue number3
DOIs
StatePublished - Feb 4 2021
Externally publishedYes

Keywords

  • AML1-ETO
  • degron tag
  • myeloid leukemia
  • nascent transcription
  • PRO-seq
  • PROTAC
  • RUNX1
  • RUNX1T1

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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