Deep Cerebellar Nuclei Rebound Firing In Vivo: Much Ado About Almost Nothing?

Davide Reato, Esra Tara, Kamran Khodakhah

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

How the output neurons of the cerebellum, the neurons of the deep cerebellar nuclei (DCN), encode information remains a matter of much debate. DCN neurons have the requisite biophysical characteristics to exhibit rebound firing and fire a brief but high-frequency burst of action potentials after pauses brought about by strong hyperpolarizations. Rebound firing is an attractive coding mechanism as it can provide a timed signal with a high signal-to-noise ratio to downstream motor areas. However, whether DCN rebound firing is a common signaling mechanism under physiological conditions remains to be demonstrated. We analyzed postpause firing rates of DCN neurons in awake animals in vivo under a number of behavioral conditions, including cerebellar-intensive behaviors such as balancing on a beam and walking on a treadmill. We did not find any evidence in support of a role for rebound firing in encoding information under any of these behavioral conditions.

Original languageEnglish (US)
Title of host publicationThe Neuronal Codes of the Cerebellum
PublisherElsevier Inc.
Pages27-51
Number of pages25
ISBN (Print)9780128013861
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cerebellum
  • Deep cerebellar nuclei
  • Purkinje cells
  • Rate code
  • Rebound firing
  • Timing code

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Reato, D., Tara, E., & Khodakhah, K. (2016). Deep Cerebellar Nuclei Rebound Firing In Vivo: Much Ado About Almost Nothing? In The Neuronal Codes of the Cerebellum (pp. 27-51). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801386-1.00002-2