Deep brain stimulation of the anterior internal capsule for the treatment of tourette syndrome: Technical case report

Alice W. Flaherty, Ziv M. Williams, Ramin Amirnovin, Ekkehard Kasper, Scott L. Rauch, G. Rees Cosgrove, Emad N. Eskandar

Research output: Contribution to journalArticle

173 Scopus citations


OBJECTIVE AND IMPORTANCE; Medical treatment of Tourette syndrome is often ineffective or is accompanied by debilitating side effects, therefore prompting the need to evaluate surgical therapies. CLINICAL PRESENTATION: We present the case of a 37-year-old woman with severe Tourette syndrome since the age of 10 years. Her symptoms included frequent vocalizations and severe head and arm jerks that resulted in unilateral blindness. Trials of more than 40 medications and other therapies had failed to relieve the tics. INTERVENTION: We implanted bilateral electrodes in the anterior limb of the internal capsule, terminating in the vicinity of the nucleus accumbens. At 18-month follow-up, optimal stimulation continued to lower her tic frequency and severity significantly. CONCLUSION: Our findings suggest that stimulation of the anterior internal capsule may be a safe and effective procedure for the treatment of Tourette syndrome.

Original languageEnglish (US)
Pages (from-to)ONS-403
Issue number4 SUPPL.
StatePublished - Oct 1 2005



  • Deep brain stimulation
  • Internal capsule
  • Obsessive-compulsive disorder
  • Tourette syndrome
  • Ventral striatum

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this