Declining ovarian reserve adversely influences granulosa cell viability

Keri Greenseid, Sangita K. Jindal, Athena Zapantis, Michael Nihsen, Joshua Hurwitz, Lubna Pal

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To identify if declining ovarian reserve adversely influences granulosa cell (GC) parameters in patients undergoing IVF. Design: Prospective study. Setting: Academic IVF Center. Patient(s): Twenty-four women undergoing IVF. Intervention(s): Mural and cumulus GCs were harvested (at time of egg retrieval). Main Outcome Measure(s): Influence of ovarian reserve, reflected by maximal basal FSH levels, on GC (cumulative, mural, and cumulus) counts and viability were investigated. Result(s): The FSH levels demonstrated an inverse correlation with cumulative and mural, but not cumulus, GC viability. Adverse influence of increasing FSH on cumulative GC viability was independent of patient's age. The GC counts were uninfluenced by ovarian reserve status. Neither GC count nor viability demonstrated any relationship with clinical pregnancy after IVF. Conclusion(s): We observed an adverse association between declining ovarian reserve and GC parameters. We believe these findings may partly explain the suboptimal reproductive performance in these women.

Original languageEnglish (US)
Pages (from-to)2611-2615
Number of pages5
JournalFertility and Sterility
Volume91
Issue number6
DOIs
StatePublished - Jun 2009

Fingerprint

Granulosa Cells
Cell Survival
Cell Count
Cumulus Cells
Ovum
Ovarian Reserve
Outcome Assessment (Health Care)
Prospective Studies
Pregnancy

Keywords

  • cumulus
  • follicle stimulating hormone
  • granulosa cell
  • mural
  • Ovarian reserve

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Declining ovarian reserve adversely influences granulosa cell viability. / Greenseid, Keri; Jindal, Sangita K.; Zapantis, Athena; Nihsen, Michael; Hurwitz, Joshua; Pal, Lubna.

In: Fertility and Sterility, Vol. 91, No. 6, 06.2009, p. 2611-2615.

Research output: Contribution to journalArticle

Greenseid, Keri ; Jindal, Sangita K. ; Zapantis, Athena ; Nihsen, Michael ; Hurwitz, Joshua ; Pal, Lubna. / Declining ovarian reserve adversely influences granulosa cell viability. In: Fertility and Sterility. 2009 ; Vol. 91, No. 6. pp. 2611-2615.
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