Declining ovarian reserve adversely influences granulosa cell viability

Keri Greenseid, Sangita Jindal, Athena Zapantis, Michael Nihsen, Joshua Hurwitz, Lubna Pal

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: To identify if declining ovarian reserve adversely influences granulosa cell (GC) parameters in patients undergoing IVF. Design: Prospective study. Setting: Academic IVF Center. Patient(s): Twenty-four women undergoing IVF. Intervention(s): Mural and cumulus GCs were harvested (at time of egg retrieval). Main Outcome Measure(s): Influence of ovarian reserve, reflected by maximal basal FSH levels, on GC (cumulative, mural, and cumulus) counts and viability were investigated. Result(s): The FSH levels demonstrated an inverse correlation with cumulative and mural, but not cumulus, GC viability. Adverse influence of increasing FSH on cumulative GC viability was independent of patient's age. The GC counts were uninfluenced by ovarian reserve status. Neither GC count nor viability demonstrated any relationship with clinical pregnancy after IVF. Conclusion(s): We observed an adverse association between declining ovarian reserve and GC parameters. We believe these findings may partly explain the suboptimal reproductive performance in these women.

Original languageEnglish (US)
Pages (from-to)2611-2615
Number of pages5
JournalFertility and sterility
Issue number6
StatePublished - Jun 2009


  • Ovarian reserve
  • cumulus
  • follicle stimulating hormone
  • granulosa cell
  • mural

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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